ID W6U4N9_ECHGR Unreviewed; 3636 AA.
AC W6U4N9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Ryanodine receptor 44F {ECO:0000313|EMBL:EUB56108.1};
GN ORFNames=EGR_09047 {ECO:0000313|EMBL:EUB56108.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56108.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB56108.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004326}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB56108.1}.
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DR EMBL; APAU02000129; EUB56108.1; -; Genomic_DNA.
DR STRING; 6210.W6U4N9; -.
DR EnsemblMetazoa; XM_024498296.1; XP_024347304.1; GeneID_36344762.
DR OrthoDB; 3144451at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF8; RYANODINE RECEPTOR 44F-LIKE PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 2.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 2.
DR SMART; SM00449; SPRY; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50919; MIR; 2.
PE 4: Predicted;
KW Receptor {ECO:0000313|EMBL:EUB56108.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 49..103
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 303..362
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 1102..1339
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 474..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1634..1660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2310..2353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2401..2424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2791..2879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3219..3239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3339..3361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2796..2816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2851..2879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3636 AA; 397138 MW; 39CC7905E7F3D3B9 CRC64;
MAYPNAYAWV PPANMPPCIF ILEQALSARA LQEMLSSRNE LSDSHTSGHR TLLYGHAIRL
KHRNSSMYLA CLGTSSTEDK LAFDVGLERK ANTEACWWTI HPASKQRSVG EKVRIGDDLI
LVSVSSERRC MQVAFGGAIF FPSALSITLC ILACMRARAN GEAANRWPCA DARERVNWCI
QAGVFWGPSL RDCACHVYGD SFSSSGVIAS FQQTLWTVIP VSSGAVRQKS LHMAFGGDVV
RLFHGDECLT IQAAGDTEEG QIISNEAASS SDYHQSVMYQ LGSVSGHASS LWQIEHTKIK
WCAGFFSWED AVRLRHVTTG RYLGITRSGA GGNPSAPGQI DVVLLSPSES DDAATVFYIK
QTKDDKKKVE IDREHEGMGE PDVCLGETLI YLQHAALGWW LSYESYETKK RGVGKVEEKK
AVLLAEGHMD DVFSLVRAQE EESLSAAAIR RSTAVFSAFN RSLDALASSD GLGGGGGGAA
GAASSPATGP GDVPLNLDEV NQCLEDLIEF FAQPETHEEH EARQSKLAAL ANRQDLFQEE
GMISLVLETI DKFTGTFRSR RDFALAVGEE RGSRFSDLGN YLYLLLAALI RGNRENCAQF
AAPARLDWLF NRLELQQSFA EGVLDALHCV LTDSDEALNV ITAQHIHTLI GLLDKQGRDP
RVLEVLYSIC IGRQGGAVRL NQDLIYESLL PERDLLLQTK LVAQSGSMRP NIFVGIKPGG
SMYTKWYFEV FIDALENVTH QPPGIRIGWG NTDGYTPHPV GGPGWGGISL GDDFYSFAFD
GQNLWTGGKA KQALFPPGTG GKGLNRRTGA SPPAVSTTSS NGSANLKRGD VIGCLLDLTG
PVIQFNLNGN LVKGYFQDFN TTGLFFPCVS MTARASARFV LGGTHGKLKH GPPAGYAPII
DALQPSQRLR LEPVFSFGRL DKSIFSGPLA SPLPSQDVFV PVPISTDKIH LPNVVERIRD
KLAENLHELW SMRKIEQGWA FGERRDEGRR RHPCLCAFDK LQQQERQYNV TMALENLKTI
FALRYNIGYE SLPEGTRMRT IKLGASYTQS NGYKPQPLDL SAIRLSSRLE TLVDELAENT
HNIWAKDRIH QGWTYGSTED NTQKRSPHLV PYSEVNANIK KMNRESATDA VKTLLAYGYV
IEPVSGESEQ TRENPLDVLE EATMNYRAAS SKAVTRGKWY YEVELLTYGM VRVGWATKNA
PAATTTGMSG SSYSFAPEQL KLIGGFLLIN RSALNTPLDK VEDWFISRLL MLLWSLLQAR
KYHRDGRPYG KRCEPGDVIG CMLNLNERSI TFSLNGEIMM DPMGQEIAFK DIKVNHGFVP
AFTLGSGQQV RINFGNVVQT LKYFTICGLQ EGYSPFAVNM SHPVPMWYSK VDASLFRDLK
PNHSRLETKV SGAYPPVINI LAKSPSPTGL HQMEYLRLSL GIQCKSHFTT RSLADRRANL
DHLRKQLEPE DYHHHGIGMG GPANIDLMTQ EIGAAGLEVR DRRGKRARLA NVFRKTRPRD
VSPDVTSGYS AGAGGVSLVS GSASTSGIVG GKKGDPATAS QTSTGAHEGS PGPAGEEFEL
LLPEQSALDN AIADFMDEFA YTVLIPPGQN PCLVNVGWVG SCFKISKPAS ISGGNPFPVD
PDFNVTQLAT TPAPIAKSTV EGDATSVASE SSASEKTSTL GSTTETDKFL NFAEVRQVAV
CLLHDDLTLK SAVAERSSFL VNVGDLIQKI STPEDIGKRV SQGLAVTCWV DTASGTLGFR
LNDRDTLIRF QVEPSTHLFA AVFVRPTARD CVQFELGRRS RYHLPLTAGM LRPPRRANMP
MPHRLNVQAI ERVHWAPVPV EQSKIQSMKM SDQRGWSMLL ENSAPRLVIQ LPEANRCFSI
LELEEMPDLL KFHAKTLALY CALCCHGNHN VAQKLTSHVD QYQFLYVIQS KYVHGSLRSE
FVKLLLSMHL ESPMKLKQVT GREFIVPLEK DDLEVTKSPA HVLKIVYDWD PDHIPAVKEH
RSIRPKLITD PYLLIPGADG TGVGNFTIPT GGGEAQPETV LNAAMAAAGP GGLIKLSDCP
PFPLDLLKRQ TLDALIDMAN TGGHVRDPFG GNFEHALLPL LLILNHLLVM GSLDAADLAT
VLGLLSPKLF PNTPSWRVTP ITGSLLELPL PESVKMEVCH LFHHLCDLQL RHRIESIVNF
ANTAVSEIQN DQLQRYLAIK VANLPSAVAA PRTREFRCPP NVQIRNLLHM PGPGGPSGLL
EEASCASASS DNEAITVLDL SDSSDDLTLD GYSRNPCAEE IKELMRLFHH RLMNHLGVVK
PGIEDTWDYE GAIKFLQEAA AAGLQQLTPT SNTVNVTTPN ATATSLTTSA STDSARHTTT
STTNTSLASS SSEQLQSELT ELLNIPTLLL PEGVGDPESG ASGPPSAVKA IWKLVSGSSD
TSTANVDGGS GASRQLALGG PEESKQHGRK LHQLILETVS DWASSSIIED VELIRQMFYL
LYRQYGALDE ASGSSKNTIT KENLRLGLTR TYAIGNRSKE DVSRLLRSLG RIRCLLGVQV
GANEEILLKN CLWDIMNNNV FFQHPDLIRV LAVHETVMQL MVHTLSKASL DSPSVAATAA
AAAASTASEL QHQGSLSPQL NAADAISLRR RQGSGGGAEL PVLVEEGEEA TLSGSNLGRN
VPVGPTEMVV QCCRFLCYFC RTSWQNQKAM FDHLSYMLEN SSMLLARPSL RGICPLDVAY
SSLMDNNELA LALREKQLEK VAVYLSRCGV QSNAELLTKG YPDIGWDPVE GERFLDFLRF
TVWVNGESVE ENANLVVRLL IRRPECLGPA LRGGTKSVSS RRQRLNSQSI GQSVVVGSGG
GGSEGMDQLA PPGSPDAAGG GGAGGGPGGG VNSAGSTTGG VDDAHSTTAS NANAASSSTG
GGLLKGIKEG IVMSAQIKLV KMAMDAEAQG LNPEDEDMGW RTVLMDYEDC NLFAPLPYNF
SSLPPEEDED YVDLGAAILT FYAVLVDLLG RCAPELDASK SESVRGRAIL QSLVSMQDLE
GVLSLRFILP PPKLEMQMNA EGLEQWVDRS PMPPGLLPEH KAAVVLFMER VYGLTDSDTF
VRLLENAFLP DMRAVTLLDS AQRGVTASDM TLALNRYICG SVLPLLTRYA HFLAVNEVTA
GLLESTLHTA YRLATCRSIT NNQRDVVSDF LVALVEHIQP FSMTSLIRKI AKNMRIVGRE
SVVSLRVLTT FYQRFGAYYS SEGWTAEYSS GGGDTKVGVG VGSGGGSSGG ASKPSRTQRV
SVAGSGAMRD LSDTSFVRST AVGTTATATE EEKNLTAELF SLIFNNLSCR RYDAELYVYA
LPCLTAIGCA LPPDYCSSHW DAQSRIGEDD TMGLDVSVHP GGPDSAADLR GSNQQHESFR
PTPLVTSSIK LPAALSILVD QFAKHCHDTW AQELVDQGYI YGLTLDEARR THPNIRSYHS
LSQRDQMRYI QPVTETLRAM LALGWTIDPS GVCHEDDGTG LGHRRRQFIH SQTESPQGYI
PAPKDLHGVN VTRELIDLAE RLADNAHQIW AKQKMEELEE IGGGVHQLLV PYDILTDRER
KRYRRLTHEL IRYLQYWGYR LSYKPTNQQV DTTKTGPAAT TNATPNAIKQ FAGERGEGEC
GRVVVAGWGI VGQWGIVFKT RRDTDVWQAV TLRRVF
//
