ID W6U6A3_ECHGR Unreviewed; 1754 AA.
AC W6U6A3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=EGR_08391 {ECO:0000313|EMBL:EUB56748.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56748.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB56748.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB56748.1}.
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DR EMBL; APAU02000105; EUB56748.1; -; Genomic_DNA.
DR STRING; 6210.W6U6A3; -.
DR EnsemblMetazoa; XM_024497640.1; XP_024347944.1; GeneID_36344106.
DR OrthoDB; 2951298at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR PANTHER; PTHR45752:SF204; GH17740P-RELATED; 1.
DR PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EUB56748.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EUB56748.1}.
FT DOMAIN 1142..1354
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 1754 AA; 191991 MW; 54A57BD4DCE50E88 CRC64;
MSSTPPRNLE VLEEAFFARI AKSAEFLNRS VKPVVRLWQL LRSLLLQRNS CKVSWATWCT
DHSLELEEAS VSGDADILQS LLELFTTSTC TYRSYTDLSF HLESVELEDL HDFTFLSMEA
DSILARPRSS AGSFQRHSIS SRRNFFNMIA EGAEKALSAI FTVGEQIRGV GGEAAIFETD
LLARRTRNVA AQLTQRYLNR MLIMAIERGD FAIINVLLDF GFRLQAIPRP SKSHLSSTIP
TADGINRRVE EKRANPIEWC LGGPSGARWL EVALHAKDDT PLLAAIRRNL LAGDVFSRLV
KVGPHLLMLP SAGGILPVHL MAALGRFEML SALLASNNVS LDIVEDCGLS ALLIASFYGH
VDCVRAILDY PSVGNEDEEV EEEEVGVEES PVMASSASAS LKSISMVEAL RSVNLQWHFL
KDGANSVVLP IQHNDSGSGG SKYFLDASFN ALHLAIITGN TELVECLLTY VKEAPEDYAD
WLTEAAVSTI CYHDDASTIK SDSVTDEAQP LANQAYASLL CSPAGLACCL DHLSVEGPLL
AKKMLCLLST VQTRKASVEN ALLHYLLDSQ RYNLVGGLLF QQHHRTNKTL IDWSNRLLCQ
HLNADARDPD IFSTLLTDWL SWSSLEALTK LNLSNNAISR IPMCLLTQLP HLQDLDLSHN
DIVALPDFAS LASVFTANTT LAPSLTRLDL SNNALITLPP WIFGVVVGAN EGGGTPLMRD
RLASAKSGVV KPNGGALGGV TFAPRLSILR VCSNQLRSVP RQMWLARQLQ CLDLSANSLT
ELPRASIEEV LSAAVLRSES PPDPDVNRAR DLSCLPHLPN SIQFITMLNC TKDAGIPSSA
SAVIIDDPGT VGHQNRGLLH LWLQGNRLPR LPLAEPTSTR QTSDEKGLQD GVGLVHLAPA
LTSLDVSGNR LTGPFPPPAL FPPNLVHLDL SNNRISTVAG GRNAGDGGEA GGGFQTSNVG
AQKASVILDG QLKHLFHLNL RGNCISVFNP VSSHGNESGG EALLWFPELA SLDLSGNTNL
ISLGSAVCRL EKLSSLELDG CTSLTELPPD LWRLGKLKSL TLFNTPAYER LVREIRAGDD
TAVRKSSRHA IINQRRRVGK SPLLSTLTDG VTAGTANNTT SPAMPILNTK TVLDYLKSLP
RSSRPYNKVR LMLIGSRGVG KTSLLKALLR SEGQDVQDAE NSASTSSVTL TPLSITRHCP
TERARNEWTE TVNFTVWDFK SPESAHSSSP IAAMVEEVES VMSAVQQFSM SRSTIYVVVW
NAMDAPDALH GVARHLVAIQ TRASNAPVLV VATHADATTS SEVSDLAERC FIRCTDPASM
GLSQQIVGHF LVDSRYSTSD NYNREALYHL VTAIHHSANY LRPPFRKPII GAKFEPGRQR
LLSFPVPLVY HELEEVTRDL ASDLHRVGIP PIVSLDDYVT EVNSRLQASS GFDSSEEVRF
ALTFLHEIGH LLYFSNLSRA VVLDPIWLCD LLVRLLITPS TAPTRAGVLK LSRLKDLLVV
PMVSTEASSV DADRIMHRFQ HLEISFALTY LVGLLAKFEL AAPLDSHHLL VPALLPLRNS
ANIVASNRQI RITPLNLVMD NEKEGEVELE GLLRDSDPLN CSVFTLPRGK KWAASVSPLQ
PVLASDLQDQ LAQSSEPVTS SRRHNIFSKF AAWQNNLVPR GLCLSKPKTV TNSTTAATSF
FQRNDRTRRP TPRGGWPTTL LQPQTPLWRL RAAPRANEVL RVYALAYVPA GFWTRLITRL
LTDTDLNNYE DRPS
//
