ID   W6U6Z6_ECHGR            Unreviewed;      1530 AA.
AC   W6U6Z6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Cullin-associated NEDD8-dissociated protein {ECO:0000313|EMBL:EUB56955.1};
GN   ORFNames=EGR_08192 {ECO:0000313|EMBL:EUB56955.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56955.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB56955.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- SIMILARITY: Belongs to the CAND family.
CC       {ECO:0000256|ARBA:ARBA00007657}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB56955.1}.
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DR   EMBL; APAU02000098; EUB56955.1; -; Genomic_DNA.
DR   STRING; 6210.W6U6Z6; -.
DR   EnsemblMetazoa; XM_024497441.1; XP_024348151.1; GeneID_36343907.
DR   OMA; AYIPHFQ; -.
DR   OrthoDB; 68829at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0010265; P:SCF complex assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039852; CAND1/CAND2.
DR   InterPro; IPR013932; TATA-bd_TIP120.
DR   PANTHER; PTHR12696:SF0; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1; 1.
DR   PANTHER; PTHR12696; TIP120; 1.
DR   Pfam; PF08623; TIP120; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1349..1501
FT                   /note="TATA-binding protein interacting (TIP20)"
FT                   /evidence="ECO:0000259|Pfam:PF08623"
FT   REGION          486..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1087..1121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..524
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1530 AA;  170099 MW;  E0EF57C5749557EE CRC64;
     MARCSNVESL IEKFGIQMES PDTDFRFMAL NDLIIGIQSG SLTQKVLSCR LVQKTLELLQ
     DTHGEVQSLA VNAVSALFPV VVEAQSISIV EGVIAGMYRS GNERCNSVSV LALKSLVNAT
     PPDNVKLLSV LATHSIPSLV EAVCNDSCSI QVECCEILGH MVSRFGEHLI PSYPNIQKCM
     LRALNSSQPA LRKRAVQMVT NFISFEDTYA ALLNFVSDRF EKVMCQADIG VRLDMPQPLE
     QQEELTISYF KVALQCLVAL AGAGHCQALT DGTRLGQLYF VARLECLEYF RGYLVFSALL
     GTTTCLNSRT KLEMLPWHLG GEFWSDEGLI IEAGATSMAV LSNSSLPYFV TTVHEKVGVV
     EELMMVMMNG GASCNAECLA SQASHLLYDG LILHLLDSDI NDTIMPHLKH EFGDLYSGDA
     ANEFRELGLQ CLYNLLRARQ RTATQSSHLS RLLDTKFQKI VYVLASLVCY DPNCVSTSTT
     KVLGGSGDDD NFKDADDDGS PVGMDYENDG EDADDDEEGD EEEDDTSWKV RRTAAKVMDA
     CVQAYQEKLG HFYAYFAPVL ISRLSEDRNE AARLEVFNCL NTMVKATTLK NPNSLKIRLR
     QQSSQSMLLR LLPGIFQSIQ PFTSASSSKR SSSRMSSPCV KTTPASHQAV LALIRALALA
     LPGHLTDQLL TIVQMVKGDF SENSTTNSVK IDLLRLLHLI IETHEYDSYK ELADTLNEIA
     LTAISDAFYR VCYEGMDLAQ ILVQRRPLEH VASMVSLFPA LLNQLKVVKC DLEIKEKAMV
     TVSTFIEQLG QDLSPECLQD TLDQFTKFLD IETTRIPAIR SLSVIFASPL SIKTCPVSRD
     LTKTLLEMLR ARDCHLRAAA THCITVICSH FPRDFILNED KNVAAILPLL PDLLNDPNPA
     VVQEALELAA AVLKQCSRCD VVQQATVADF YTGEKFLDPV IGLTHSSSIS STLLTALLHL
     MQSIGMYRPE SHKLSVKFML EKVLEPLADY TSVEMSENFL LIREDLSILA RVCAELILQL
     PRYGQLNSID STMEEMVAEL KKKTTPYARR YLYIIIFGDV GYRIDISHRG DVFDILMDHV
     VMNKSILPST DQQPPPSDEA PTSSSPLPSS TSATASGSGS GFSELRPLAV ASLGRLIAGE
     PSVTVHELLQ FFHQEYEQNL VVFYLLQTLR QAIINLVEVR SAEYIYRNVE EVWKILMSHA
     THPEEGTRNT VAECLGRVTL LQPAELVPRL HAELKSPNSA SDSTIRCTLV TAFKYLLSVA
     ASINYPDDEN GMASVSDTAN STDASVTTLN DRQELVQILL QDSRFLDVLA YILDRDPDVC
     RAALITFNTA AHFWPTLIRP LLIAPIGPKQ KPLVEEVYRG TVVRQDLIRE VQMGPFKVYF
     DDGVELRKTA YECMSTLLEN HTDRLSMSTL LDPLIEGLRD NNHVKLVVCH ILRRVIQLAP
     IDIVRKMPEL SQALTAILQL QPKGDLVKRE TEKLEEVKSC ALSVIADFPK IPDMRKNQFF
     CELIKVIRSE KTLTSMWMEV VGGESFLTKV
//