ID W6U775_ECHGR Unreviewed; 1029 AA.
AC W6U775;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Superkiller viralicidic activity 2-like 2 {ECO:0000313|EMBL:EUB57030.1};
GN ORFNames=EGR_08106 {ECO:0000313|EMBL:EUB57030.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB57030.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB57030.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB57030.1}.
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DR EMBL; APAU02000096; EUB57030.1; -; Genomic_DNA.
DR AlphaFoldDB; W6U775; -.
DR STRING; 6210.W6U775; -.
DR EnsemblMetazoa; XM_024497355.1; XP_024348226.1; GeneID_36343821.
DR OMA; IMLKNYN; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 136..292
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 363..564
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 340..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 116067 MW; D3A8D6EE1ECFAD1D CRC64;
MSNVFGVDID ELASVFEDKG TGEIPIALVK SKDAGQVDEE FEKKKRKVEE NLREHINIST
KEEHVEPSKD PKLSSVLEST LSKAPRIKIY KIPAPSTCTH EVAYPPGIPF KRLEVISEPK
ILTFPFTLDP FQSQALLCID NNESVMVSAH TSAGKTVIAE YAIAKALRDK QRVIYTTPIK
ALSNQKYREF SEEFPEVGLL TGDATININA SVLIMTTEIL QSMLYRGSSI MREVGWVVFD
EIHYMRDPER GVVWEESLVL LPDCVRFVFL SATTPNARQF AEWIAFLHAQ PCHVVTTDTR
PVPLRHYIYP LGGDGLYLVL NEGNYIEENF RKAMASFPKQ KELGGPGTSR AKTGPMSKKT
EDNVSKMVRL VKKHNLEPVI VFCFSRKECE IYALKMSECD FITPADKNVV EEVFKNAIGG
LSPEDRCLPQ VESVLPLLKK GIGIHHGGLL PILKETVEIL FGEGLMKCLF ATETFAMGLN
MPARTVVFTS VRKYDGVNYR WITAGEYIQM SGRAGRRGKD ASGTVILMVD ETLTEQAGHA
ILQGKPAPLN SAFHITYNML LNLLRVEEIN PEYLMERSFC QFQNYSRLPE LSEELNRLQT
ELSTTVLEEE KAVESYRKIQ LCLQEIVEQQ WRYIRRPEHI VSFLQPGRLV KIESEGDDYG
WGVVINLKKR QRNDRVSALE TFYVLDCLLA TRPTADTAGA DEAPSTSAPK SAEILPVRLD
CVCGISAVRL MVPQDLRSPE ARSLLYASIE KVKTKLGVAD LPHLDPVRDM HITDAKFKEI
TEKARLFEQR LEAHPLHKSP RLPELLGAYE RREAQRRRID EVTRSLTQKV SLIQMDDLVG
RKRVLRRLGF CNEHDVIELK GRVACEITSA DELVLTELLF EGIFNRLSAE QVASLLSCFV
FDERASEMPK LSAEMADALR TLQDIARRIA RISRECHLPV DPDSYVDSFK PYLMDLVLSW
AHGATFASVC AGTDLFEGTI IRCLRLLEEL LRQMTNAART IGNAVLEAKF SEAIEKIKRD
IVFAASLYL
//
