ID W6U7P3_ECHGR Unreviewed; 703 AA.
AC W6U7P3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Neuroendocrine convertase 2 {ECO:0000313|EMBL:EUB56376.1};
GN ORFNames=EGR_08746 {ECO:0000313|EMBL:EUB56376.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56376.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB56376.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB56376.1}.
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DR EMBL; APAU02000118; EUB56376.1; -; Genomic_DNA.
DR AlphaFoldDB; W6U7P3; -.
DR STRING; 6210.W6U7P3; -.
DR EnsemblMetazoa; XM_024497995.1; XP_024347572.1; GeneID_36344461.
DR OMA; HALLTEW; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016486; P:peptide hormone processing; IEA:UniProt.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 526..673
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 229
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 270
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 447
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 703 AA; 76987 MW; 745BA36D2DE329FE CRC64;
MDAPAMIDDF TRACGHGPMS VEDANCPPQA LSLLPLMHQL RLLMARQGVL GCLVVLWLSV
SLISARIRTN QWLVRLQTDG QEDRDALKAR AKQIAAETGF RMWLEDHNTY FHPNEFLFLH
PNSKQPSKAI HDTLVGHPSV ESAEQLKGYK RMKRGFRPIE EEEKESAGRA LSPSEAEIVR
GLSSDPLFRK EWYIYNTGQA EGTPGLDLNV LAAWAQNITG RGVVTAIMDD GIDYLHPDIA
PNYAAEASYD FSGNDAFPYP RYTDDWFNSH GTRCAGEVAA VAGNGVCGVG VAPDSRVAGL
RMLDQPYMTD LIEAAAMSQA RDIIDIYSAS WGPTDDGKTV DGPRNQTMQA IVDGVNKGRG
GKGSLYVWAS GDGGPEDDCN CDGYAASMWT ISINSATNDG QTASYDESCA STLASTFSNG
KSMLSLDAGV GTVDLYGNCT LHHSGTSAAA PEAAGVLALA LEANPELTWR DMQHLIVLTS
KRNHLYDREG THNWTINGAG LEFNHLFGYG VLDAGDMVRM AKLWKTVPER FHCIAGIFNG
RKVVTVGKPI QLELYTESCQ GNPESQVNFI EHVQAFISIR ASRRGDLVMF LTSPMNTTSM
ILGARPKDSD SRRGFTKWPF MTTHMWAESP RGTWKLTVGL DPQKHRSHGG EDPALGHALL
TEWILMIHGT QKSPYIALPE SASQLVPKLG LVKRQHLSER FSA
//
