ID W6U800_ECHGR Unreviewed; 1029 AA.
AC W6U800;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Tumor susceptibility gene 101 protein {ECO:0000313|EMBL:EUB57290.1};
GN ORFNames=EGR_07826 {ECO:0000313|EMBL:EUB57290.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB57290.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB57290.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB57290.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APAU02000088; EUB57290.1; -; Genomic_DNA.
DR AlphaFoldDB; W6U800; -.
DR STRING; 6210.W6U800; -.
DR EnsemblMetazoa; XM_024497075.1; XP_024348486.1; GeneID_36343541.
DR OrthoDB; 37962at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR23306:SF3; TUMOR SUPPRESSOR PROTEIN 101; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..145
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 327..395
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT COILED 281..315
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1029 AA; 114074 MW; 1D5A27FEAE8E1E0F CRC64;
MSSQSASLVH GLVNYKYREA ARIDIEKASQ AYHSLQVKLQ DFTFENGQTS KLLCMEGTIP
VKYMGNVYNI PLAVYFVRQH PYHPPIAYVR PTSSMQIKAG PNVDTNGKIF LPYLSEWNFP
DSSTQGLLEI LQNVFGQRTP VFSKPTTGSV GFNANITSSN GYAYGMPGVG WGGMPGLPGS
TNPALSGSAT PQSSLFGGVM PSMPTVSTAS TFMGSATSFP ASVVSEEEQL LLSLRSAVMD
KLNNVQREVV DDLSCEIQSL ESTQKDLISH ADNLVTIQAQ MLSELEQIQS LTLELEDKTR
EYKEAYRKLK QEANVKVDYD SVVDTTRPVY RQLVEAFAEE QAIGDVLYYL SQALENGAIE
LEDFLKVVRD QSRNQFMQRA TVCQCRAKAG LPLKGGVNFP AESSLGELEY RSAVLPTNQN
AGTLENQQIM TPSDFQYFTV YACNGEQTKR NCSKSPTQMR IENDIAESLS NEFMSLNRRR
QIERGKELLR IIELGLGDFR EIFNLQPMDA YSSYVLRLCQ VELSHAQSQT MDDCLSREVQ
TERSRTAPYS SWTQIPPAYE GGHSGHVRYA LIPSQDQQTL AELECVHCKF LDHHLLTLHR
LKSPHSMENL RGPLPGDLAC VWKVNDHSGQ GTLEHALKCP GLLPMSGRGI GDVWGYGDGI
VSVLSETSSE FTMIVGGLSD GTLVVWAIGS EISPLYPSDN VSKQGSFLPK IFEHAKSPDY
LASFAFSEED KSSDFRTFPT SPIVALKSLM RESILSNSFQ FCSLDNRGNV NIWMALRLQP
KRSCDIIGPS ADLGLRPGGR ARLIQLARFT YDTQGSHLRP VSSGINVSLA PFTTCLEVCR
TSDKFFIGSA DGNIRQKCRV PSQCIYPRDF KLSFADAAVT CLALHPFLPN VLIAGYSDGQ
LALYLTHHPH PIFKWLIKVQ SDRPSIGVRK VIWSPHRPNV TYCLATDGDI IAWTLLDGEQ
ATMKPRAQTL IIGTIRERRV VDFSVARGCS GCLAVCWQDG AEIHWLKEDL VVRQEDELLA
LESVLNGLL
//
