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Database: UniProt
Entry: W6U8J4_ECHGR
LinkDB: W6U8J4_ECHGR
Original site: W6U8J4_ECHGR 
ID   W6U8J4_ECHGR            Unreviewed;      1548 AA.
AC   W6U8J4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE            EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
GN   ORFNames=EGR_08459 {ECO:0000313|EMBL:EUB56731.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56731.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB56731.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC       {ECO:0000256|RuleBase:RU362081}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC       ECO:0000256|RuleBase:RU362081}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB56731.1}.
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DR   EMBL; APAU02000106; EUB56731.1; -; Genomic_DNA.
DR   STRING; 6210.W6U8J4; -.
DR   EnsemblMetazoa; XM_024497708.1; XP_024347927.1; GeneID_36344174.
DR   OrthoDB; 5480493at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR   CDD; cd00371; HMA; 3.
DR   CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR   Gene3D; 3.30.70.100; -; 3.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 3.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006122; HMA_Cu_ion-bd.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 1.
DR   NCBIfam; TIGR00003; copper ion binding protein; 1.
DR   PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR   PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00403; HMA; 3.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00942; CUATPASEI.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 2.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 3.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS01047; HMA_1; 3.
DR   PROSITE; PS50846; HMA_2; 3.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362081};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU362081};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362081};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT   TRANSMEM        562..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        621..643
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        655..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        686..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        862..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        889..907
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        1458..1479
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        1485..1508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   DOMAIN          3..69
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          391..457
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          474..540
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   REGION          1088..1108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1548 AA;  169134 MW;  5FB541AB50D16F3D CRC64;
     MFVPCIVHID GMTCQSCVST IQNTLHCVNG IFVVDINLQE KQALIIHSPT QISVDEVTEV
     ISGIGFDAHF MTNRIETSSK RGSIVPSVSS AESHPSEIRH QSFRFYSSDV AIISQYLYTL
     PGVIYFSIFE KESRIDLWIL SNSLIDQELL CKLNKQGFRV VLADSSVAES TSAEFDPLNS
     SLRLPGNKAY LIVDALPSPE IEELRRRLNL ASLSSLAVCR VGQAYCHLVT LSKGLDTRSI
     ADILTGNGFP SARIASVGTG FEVYVSIYGV CCKVCEDEVL NVLRHTLPDD AFQVLMDQDE
     IILASHSSIP SATDFLAGLH LTQLHNAITH LGYSCHLRDL SGIHCPSKPD DFSTSVTENG
     RTTLKSPVLS EEVKVGEMTT IDLEPPIHAL KCCHLRVTGM TCSSCVQTVE NALLKLPGVR
     SATVGLLSMK ADIIYDPTLI QPSALTRQIN ELGFSAQILE VRRAAEIHGD EGTQTLEVTI
     LGMTCSSCVN SIETAIKKLP GVTSASVALA TKRGKVVFDS RIVGARSILK TIEDMGFDAS
     VYKPEFKSTE DFDETKRWRC VFLTNLAFGL PTMFAMMLFM LIWPHSPVGG YCHPRSYNTS
     KETSPTHSQP MLLPGLSWEN FILWLLATPV QAISGRNFYI RAYNSLKHGM ANMDVLLVMA
     SGVAYTYSVV VVLIAMIQQW PTSPRTVFET TPMLFLFISL GRWLENLAKE RTSEAVSKLL
     SLQAKEATLM EPQSGALNEA FSGEQLTIDT LQNYQERCIS VELVQRGDII KILPGEKVPV
     DGRVIFGISS CDESLLTGES MPVPKTVDNI VVGGAINLTG LLYIQATHIG SESALAQIIA
     LIEDAQSSKA PIQQLADRIS GFFVPCIILL SLASLIFWIV LGFCRSSSIR GYTVSIVFPL
     LLPPFAFSPE CSLVGAVLDQ AFRVAVNVLT IACPCSLGLA TPTAVMVGTG VGALHGILIK
     GGQPLENLRK VSTILFDKTG TITMGRPQIS RIVMFMPATP SNPESKNQKV DPHALTSPSR
     LLYMVGSAES TAQHPIATAI VRMLRSAQSA FSDQPNGSIW KSEFAKVINA ETSPGYGMSC
     DVIVSPEDCP SGPELPRPTR LPSDRQSVQQ TQLYADYDAA LRMELNYYSV RWNSDNSPLS
     WANVTQGGTY HLLIGNQRWM QKNAVAIPLM DLDSVVRMDE EEGRTVVHVA VDGRLVALIT
     IADPIKPEAA LTVAALKVMG IHVALLTGDN TRSATSIARK VGIRDVYSEV IPAHKAMQVR
     QIQTRHVKAS GNGLSKLNQT AMKNGKVEGD THCSGERVAF LQSSKHPDTL DQTAETSFLE
     YSYSDTDDDS EASLYLYPGD LGVPIERSGR KRFFDDRKGK YTYIGQRNKR QWRNRRCFCA
     WCGICPTAPR QRKREFVAMV GDGINDSPAL SQADVGIAIG CGADVAVATA DVVLVRNDLV
     DVVAAISLSR ATVRRIRLNF FAALIYNALA IPVAMGFLIP IGIEFAPWMS SAAMATSSVT
     VVCLSLLLKR WKKPTEASLV SQKYLRLLTN SGLTIDQVRV KRDNTPNK
//
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