ID W6UBT4_ECHGR Unreviewed; 1685 AA.
AC W6UBT4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=PWI domain-containing protein {ECO:0000259|PROSITE:PS51025};
GN ORFNames=EGR_06277 {ECO:0000313|EMBL:EUB58853.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB58853.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB58853.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the DRC1 family.
CC {ECO:0000256|ARBA:ARBA00009688}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB58853.1}.
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DR EMBL; APAU02000054; EUB58853.1; -; Genomic_DNA.
DR STRING; 6210.W6UBT4; -.
DR EnsemblMetazoa; XM_024495526.1; XP_024350049.1; GeneID_36341992.
DR OMA; VMANENK; -.
DR OrthoDB; 5476746at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR036483; PWI_dom_sf.
DR PANTHER; PTHR21625:SF1; DYNEIN REGULATORY COMPLEX PROTEIN 1; 1.
DR PANTHER; PTHR21625; NYD-SP28 PROTEIN; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
DR Pfam; PF01480; PWI; 1.
DR SMART; SM00311; PWI; 1.
DR SUPFAM; SSF101233; PWI domain; 1.
DR PROSITE; PS51025; PWI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 868..967
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 570..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..229
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 257..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 595..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1088
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1118
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1368..1395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1427..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1488
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1544..1572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1573..1633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1641..1663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1685 AA; 194862 MW; 010EB1D3E803E4E3 CRC64;
MYANTVAMDM HTRKLYFGHE EDRDKGPSAN SDDLEERIAA RRLRISERVA SLRPDYFDEK
ASIDEEAAVT ATSNPLANAQ VALSAQRIVN LCRNGNAFIT NLKVACDARE NLRRVEEEEL
DNVRQAKFDA EQKATTKLFE EVEEKWEEAK TTKGAHELHD IFEELKTNCA KIIDEKNKLI
YDIHLELKAK DDHFVKELRK RTEDVDIMVE RMESQMKSMQ RAYDFELKEI EKAFLQDRED
LLREQTTDWE DFMRELRKKQ EDYLEERKNR ITELEELIQK LRINHTEEFN ALKLRLTTEV
QNMETDLQQM KAMYQLNLEK LEYNFQVLKR RDEENTFTRS QQKRKITQLQ DQLNRLRVFS
KKQEESLRHE NLVLSDDYKK MMEAFRDLQK KSKSLIKFEE QNFRDVWNMN EDELRKDAEK
LMAADKVIME QQLGLTWTPP EVPFMNNSGP ISLAEKERRT TSIAARALQL PTYKSRSVNI
RKLPKCRLPQ TLKEAPKEIV GQFLTMLAFE PEFLIEVKVK KLLKDLPFDD QKLIRLDAVL
NVLKVNSEEL LDKLFTYFIL PCDSRRPQPL TMSPPVSAAF GQDMQPDGEK SEPQECESQS
TTPPESLAQT EAPTFNEEVE FSAIRLIDPI DVPQVLHRFA VENCVHATVA AFERAMENTA
PVTTSSPEDV VNEAEEKDGA TKATHRISAR QQDLLDMEMD REHWYKYLNT FAPDEKRRMW
AGLKQTLQRY LTILQARSRL IVENEALRSQ NIELRHLLQL YSQSQWSPWM QQKDLELYKG
RKVLYSSNER KEELSQYIKS PIVKGINPLI HFVVYESNLE IKILIGCKVG GIAWLTSDSK
MTDAGFFKGT NTDQDSRFAD KKKKLLKSMK FGDNLNEKVD TQRVNVDSIK PWIVKRITEL
LSYEDDIVCD FVVNMLSEQF PDPKDIQINL TAFLGSKSAR IFVTELWDLL LSAMNTTGGV
PAILLEARKA EILGSKAQEE RFRAEQASRQ SEGGSAGSGG GMVNRPRERG DGPSPNHPTS
PIAANQRHRS PPSPPRGERK EVDSRGRNRH RYSSSPDSER ERSRSRRRRR EEEEAEAEAA
EQSDWDRRRR RHRRSYSRSP SSHRRDYHRH HHRRGHRSPR DRRYEEMEVE ADIRSFHERR
RPRLSSREGR RPREEERERV VHNADGPICV PRAGTPSPPP PPSQRQQSSP LTDAKVNGGK
TDAEESVERS HRGGKSPRRG VTRSPPREDR SRRTDEVYRE ERRPRDLDTD KRAYKERSSW
RRDDSYERRR SGRLTMENET YVEEHRRHDN HEELEDRTKL RQRRDKKPVE EREELEQHQQ
RLMPSTSSSS RRSPEGPTLP PGERGGRKDR REREDAPQAS PEGPELPKGL AKQRKEKEEE
KVEKVQKKTK KRRDSSSSSS SSSSSTSSSS SSSESSSDEE ESSDSSSSDS DSSSNESDSS
SSSSSSSDDS DVRRKGKKGK NSKAHGKKGK STKRRKMRKL KAKEKSMKKK KREMQMLKES
TKKNKREPQQ LLSPEGPKLP PPAGELESPG VEWKEKRREG DVNEAPSSTS SSSSEESYSD
SSSSSSSSST SSSSEEKREK WRKGLSKHAP RDDDAVEGDK ERGRKRHNDV NVTESRGDGG
KRRRRTGDAD VTEGRDKEEE EDEDGLSRRR GSSSRSEEDR LRRRALESLK RKNAAAEASR
LMDSA
//
