ID W6UCL4_ECHGR Unreviewed; 2283 AA.
AC W6UCL4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN ORFNames=EGR_06728 {ECO:0000313|EMBL:EUB58441.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB58441.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB58441.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB58441.1}.
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DR EMBL; APAU02000062; EUB58441.1; -; Genomic_DNA.
DR STRING; 6210.W6UCL4; -.
DR EnsemblMetazoa; XM_024495977.1; XP_024349637.1; GeneID_36342443.
DR OrthoDB; 1052588at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR CDD; cd07920; Pumilio; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR033712; Pumilio_RNA-bd.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF212; DYNAMIN; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00806; PUF; 8.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00025; Pumilio; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50302; PUM; 8.
DR PROSITE; PS50303; PUM_HD; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 774..1129
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REPEAT 794..829
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 830..865
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 866..901
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 902..937
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 938..973
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 974..1009
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 1010..1045
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 1068..1103
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT DOMAIN 1317..1594
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 1814..1920
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1951..2065
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1924..1943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2066..2159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..659
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2076..2100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2120..2144
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2283 AA; 250980 MW; 6AB9679BE886F94B CRC64;
MNEFTDPNAP GRPFSSVSSE ADGAPDSSRF YSGMQREALP LCNGSKKFDT SGNGVGYEWS
ATEESSIADF KQVPRRSREI PFDDSKSIWN SSYGPLNVTN AQSSRIWGFG NPTFPETVAI
KDSQRDTPLT RVSQTPYNCL SNVGFGYGGG LPMSPVNKDM TEIGQQMIDH VLGNSPNNAC
DQLLSAHAQV ASVDNMVSQF LSSQSRPDLH TVPTDQAASS PYHATAEQPL NSLPVPLLEN
GGGIGMKEAH LPQASVPPID SSSVASILNN SAAVSNLSRY LATQAETFQN QQSGCPPQNS
AMPRDIAFLT AQIGAMRMDP HHQTTVPSFL PPITTSSFTN GFTHSVAGDL TGPMSTANFT
SGAFNGPPAA QLSSASCLLP PDQMAAGFYP PTQSGTSSVA YFSGAPFDIR GPTPTQPPLS
LLGPESVRTP GVQSNDIPVG VPTALATQQA AYYAHLLAAA MNGGVPSAAP RMTITVPPSN
LSHNGGAVSG GPVTTPCAYE PHLQNQSSLT SQGQYNVEKF EAYSDFPDGG GNGLTTTILP
PGSTMLQQLP PIAFNQQRPH PSFVPSRLSA LPMNQQQQPH AQRSPLSDPR LPLTPTVGAN
FCFETPITPA SHYATTPSPF APMLPPPFPN ANVAPPDCLP VHPSTPDLSV PPQGFPSSFP
PMGFPRRFIT PPPSSSSSQR RPQLSRPPPV ENPSFIAVPS RGIRGLQPGN QQRLLLFKNQ
AVNLFGPNNV AGSAGAGSRM PFMSQSVPTP AMFSTMASSV PGVFPAVSAS AMPERSRLLE
DYRYTRMPFL TLHDLVGHIV EFAQDQYGSR LIQQRLEQAS AVDKIAVFRE VIPHCHVLMT
DVFGNYVIQK FFELGTPEQK RTLVQQIKGQ VLSLSLQMYG CRVIQKAIES VNLETQINLM
KELEGSVLRC VKDQNGNHVV QKCIEYVPSE HLQFIVDAFK GNVHSVSTHS YGCRVIQRIL
EHCSAEQTAP ILEELHQCAE SLFEDQYGNY VIQHIFEHGR TEEKSRMITR LRGRVAALSV
HKFASNVIEK AVTNASRKER QALINEVLQN VDPNQTQITP VECLDEREGT SILWNMMKDQ
FANYVIQKML DVAEPPIRKE LMAHIRPYIN SLRKYTYGKH IIGKMEKYYL KTVSSSHIPY
FPPEELDNAS LHSSSSLTGS SNLPTGGSIV TADENSHTSP PRSEFLRHAT ASGNHCASSE
DGNQLVDTEA ALASHWEYSP TWGFEFIVDL GHLQSGGCSA WTLNVALKVV KTLQSFKDDD
DIIMEVSWIR ELLISVAPPS SRRVGLRKMS GNVGMERLIP LVNKLQDAFS SLGVPLNLDL
PQIAVVGSQS AGKSSVLENF VGRYEYLPTH LLHRDFLPRG SGIVTRRPLV LQLITSDTEY
AEFLHLTGVK LTDFDDVRKE IEAETDRETG TNKGISNKPI NLKIFSPNVL NLTLIDLPGM
TKVPVGDQPS DISTLIEEMI LQYINCDYCL ILAVSPANSD LANSDALKIA REVDPQGLRT
IGVITKLDLM DHGTDARDIL ENKLLPLRRG YIGVVNRSQK DIEGRKDITT AIAAERKFFL
SHPAYRHMAD RMGTPYLQRV LNQQLTNHIR ETLPGLRNKL QSQMLAMEKD VREYKAYQPA
DPSFKTKALM IAVKSFEVEF TQTIDGSGSE IDTKTLSRGA RINRIFTERL PYALAMLHND
GEELRRDISF AIRNIHGIRS GLFTPDLAFE TIVRKQIERM KDPSLTCVDL VVEELIQIVH
DCTNKMDCFP HLRDATERIV TERIKGRQAD ARDKICLLVD IQLAYINTNH EDFIGFASAE
QQSSDVNKVK LGNRVIRRGW LGLQNIALIR GGSKDFWFVL NAETLTWYKD DDEKEKRYVL
LLDGLKVKDV ESSFFGKKNV FALFYPDGRN VYKDYKQLEL SAESAEMVDS WKASFMRAGV
QPMKPIQQQQ HQEQSDEQLS DNGDPQLQRQ VEVIHNLVDS YLKIVHKTQR DLVPKMIMHI
IVNESCIDMR MASDFPVERL KRSFDLQMKE FLKSELLPNL YQAGDIQVLM SESLEMQTRR
EETLRMYEAL KEALRIVGEV ATNTVSTPVP PPVMDDWTHS TTSHLADSGS SSSSLFPTSM
GSGGGGAGGG VGVMQPPRSP GGTRRPPPQP PGAPHRPTPS PQRPSFTAPS TGTLPSPLIP
QLNALRPSVV VPYGLPNDGI SSGAVVNSSC LQNGFYNPPL PSPNPLLQHP LPSIQRCFPI
PCDSCFPAGV GSLIESVDNQ PFYTLIEKTF TMGQVRTAIK LLITTCVLYT AIIGLPQDWW
VAI
//
