ID W6UD48_ECHGR Unreviewed; 1323 AA.
AC W6UD48;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Tyrosine--tRNA ligase {ECO:0000256|RuleBase:RU361234};
DE EC=6.1.1.1 {ECO:0000256|RuleBase:RU361234};
DE AltName: Full=Tyrosyl-tRNA synthetase {ECO:0000256|RuleBase:RU361234};
GN ORFNames=EGR_06392 {ECO:0000313|EMBL:EUB58721.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB58721.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB58721.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-
CC tyrosyl-tRNA(Tyr); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706,
CC Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034238};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10221;
CC Evidence={ECO:0000256|ARBA:ARBA00034238};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU361234}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB58721.1}.
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DR EMBL; APAU02000056; EUB58721.1; -; Genomic_DNA.
DR STRING; 6210.W6UD48; -.
DR EnsemblMetazoa; XM_024495641.1; XP_024349917.1; GeneID_36342107.
DR OMA; CHRATYY; -.
DR OrthoDB; 1405752at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004831; F:tyrosine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006437; P:tyrosyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR002547; tRNA-bd_dom.
DR InterPro; IPR002307; Tyr-tRNA-ligase.
DR NCBIfam; TIGR00234; tyrS; 1.
DR PANTHER; PTHR46264:SF4; TYROSINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR46264; TYROSINE-TRNA LIGASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01040; TRNASYNTHTYR.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50886; TRBD; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU361234};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361234};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361234};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361234}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU361234};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00209};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00209}.
FT DOMAIN 839..945
FT /note="TRNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50886"
FT DOMAIN 997..1304
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 529..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1323 AA; 145345 MW; F4C44ED6EDF3ADAE CRC64;
MCEEKTRYSL VVQNLQEVVG DAELRTILQN SDGKVLEVYW GTATTGKPHV AYFVPICKIA
DMLHAGVKVT VLFADLHAYL DNMKSPWSIL CHRATYYETV IKAMLESVGV RLDQLHFVRG
SDYELSRAYS EDVYRISADT SVRDARKAGA EVVKQVANPL VSGLLYPLLQ ALDEEYLHVD
AQFGGVDQRK IFVMAERILP RLGYRKRIHL MNPMVPGLTG DKMSASEAAS KIDLLESSAS
VHAKLATAAC PPGQRAAEGN GVLAFIKFVI FPLVNLAASG SGVKVGETHF ATFEELEDAY
VAGVAGVSPE TLRACIFDHL DPRIEVVRQR FTEPRFSKLL SDAYPADEAM CAEKHASESA
GSSLTATFKD DRLTALKSCL FSTESQLPSL DATSMRSVAD ILTLRPEALK SLKPRRVLRC
MWSIAPAGVP HLGHTLPLRI LAQLSRIVGI HVIILIDDIG AFLEGNCPWE ARESRCALFE
RVLRAVFKAF AGDEKALTIV RGHDFKCEGS YMLDLYRLVS LVPEKEAFDC SGATTPSSQR
QEQAGDARGE GEEEGSGLNL SALLLPCTAL LDAYHLEADL RLSSPRSVEG QEKFAKQFLP
RFDTSHSPPL FVPHALLPAL ITGTATEEAA VMTTFVPPLR DPRMAQSAAA QAVGRVASER
CLPLIEPPPP GVPAIASSLI LPGLKRRLKQ AFCQPGNVHI NPLLEIFKAV ALPELAPGEN
LVLPRPEQHG GPITLTPSEY NGASCHLDDL FANEVWHPGD LKAALEAALL QGLQRRLVEY
LPPADLSRLI DDAFPVPGKK SKKATPGKSK YTEVKTVDNV KEGRLSEERK NAAKLDEFDP
SLLEVRVGEV VDVKPHPISA DFNVCRVAFD AGAKDRVSVI GLPAEALMHK KAVFLTNLRP
CDIGGVTSEV KVVCVGDKEM LQCPHHTLGS VLRFQAARRE GRRAKAATNT TIIDPEAHPG
WRAFFADVYY SPDGDGALCW RQNWRLSSNL ARPRICESNA YILPPADDVV IYRSSPDNRF
WLKTIKLEQC DRNDLASLLT FISNVQKISP FRVFACDSSE PLTDNVHFGL FLPKLISLLG
TELTLSYPLC KSGTVHELLK PYYVDGGLPE SLVAAIFSRA VRSLNKLHHL GWIHRAICAR
HLLLHPSSEN SEDCLDVSFC GLGSIASVRP LGSMLNRADL PVIDAGWRGW HYQNLQETVY
STHPVAWYSP EMIAQDFEGY GKPADIYSLG MALAEMFTGI APFVGTITPS LIFLKKLTLR
EPLSLPCPPG QAASGDMLTT FESCTHFDPD RRPTAEDLLH TPWVQRGLAT PLRESLLTSF
RQQ
//
