ID W6UDN7_ECHGR Unreviewed; 1389 AA.
AC W6UDN7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Rho GTPase activating protein 39 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGR_06026 {ECO:0000313|EMBL:EUB59163.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59163.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB59163.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB59163.1}.
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DR EMBL; APAU02000049; EUB59163.1; -; Genomic_DNA.
DR STRING; 6210.W6UDN7; -.
DR EnsemblMetazoa; XM_024495275.1; XP_024350359.1; GeneID_36341741.
DR OMA; WLREMAT; -.
DR OrthoDB; 5480623at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF8; FI04035P; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 19..46
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 712..866
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1088..1285
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 85..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 150084 MW; 1926A555F5CF1697 CRC64;
MDSKSSNQDL RPLASEQWWE LYDMNTQRHY YHNVRSGRTE WHRPSSGDVI PLSNLQLIKQ
FANSGGTMDK DIGVMHRYRL CPTGGARNSI HMTPQDHRKM SSPVSATPPV SSRHPVAPSP
GRPVSHRRRN SQPTHSAPAV TCHASLQQQS LTRCAAASSL SVTANQRVTE WLRSAGSLPE
EAEDEATYFQ HQKAFASSVA TQTPQTRWNT ARGIPTTVFQ PHPPLTTRRT VSNRQMSPSI
TTPYDRRIVS MVPAPPPPPP LHGRTSVDSN AAVIATQESA FANLLYDMSC NVVTPQHQQQ
QNLSTTAVNA EMAALALTPR AIPRTNPHAV VTAGTMPRLS SAKPHLPSLQ PPLPIAVVGA
TVGAPTKLKN GTGAVSVTGV VSSSPDTEIT TNSASASASA SYSSDSEPEE KEPQAMCKEA
PMSANDVSTY SKEDIFEQHP FRPAADLPVD EYTFTVPRQQ QQCHSQAIFH NQHCLPETHN
NWSLLSHQHQ QQPHSMVLMD DADQAPPTPP PRLASAMNTM QLSRVPRTTS AAATTTLPVD
SATWQNLDIP LASGFLPRNH PFRQPLKQPS YTNPALNTVA SAEDDTPEDS GLIHTSTRSL
LSASSSAHEG AGGGTTGSTH SPFSTSAAPL HPRRSASGGF IGPADSEVAS LSSSSATATA
ARPSFDQPTS VVSTSATIAC SGSTHFALIS GPYLWPKNLL RQGQDCTALM SWTKVAFSKR
LLAATDKSLQ KHISENFKLI QSFMGDRSAK LSKPDLASII VQRALSTPGV RDELYAQLCK
QTTGNYNADS LMRGWELICI CLYFFPPNKV FRDPLHAYLT TRSEALSIAL APPPLSSSIS
STAANATNDT PALRPGPSLA AAAALAAGSD PTGLIAAPVT PAFGVPLADT GGGGGENICE
TSADPALSSE FPYGPWVKLS ALHFTRAAPR WFMRSVALGA VRSSIPPSKE ELLHVKDFLL
KPGIFGSSLE EMMKIQSCRF PSLRLPWIQI FLTEELLRLN GAKAEGIFRV SADQDVLTSV
RFQLEKLFEV FRVLEVASRD PISTFTIVRP PPRGWSHSQQ VFSPEPASTT LSAPTPTTPT
HNALLHCPAL TGPFSLPLKP SPIPSRPAEY MLLTPRSLWP GDLTGFREAA GGSTAVGCGG
SEKGSFLDPH LAAALLKLWL REMATPLVPP ALTVEVFAAA VEAESFEKSV GAAVPGAEPI
EKCCAMVRRL PGINRRVLLY LIKLCQHLVR PENACTSLMD ARNLATVIAP NLFRSASNNP
SELLNSVQSQ TAFTRLLICH LNVDAEAALL NASAVEADYE VETVVEDKWE FKGADKIGDY
KVTKKFLRLS TQLAAMICTW SRLENPNNHL CLRILRHELT FVHRARDSTL YALPYSSPFK
PNLIPKGAD
//
