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Database: UniProt
Entry: W6UDX0_ECHGR
LinkDB: W6UDX0_ECHGR
Original site: W6UDX0_ECHGR 
ID   W6UDX0_ECHGR            Unreviewed;       431 AA.
AC   W6UDX0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   03-JUL-2019, entry version 27.
DE   SubName: Full=Glycine receptor subunit alphaZ1 {ECO:0000313|EMBL:EUB59228.1};
GN   ORFNames=EGR_05956 {ECO:0000313|EMBL:EUB59228.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59228.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB59228.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y.,
RA   Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EUB59228.1}.
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DR   EMBL; APAU02000048; EUB59228.1; -; Genomic_DNA.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019149};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EUB59228.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    431       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004881989.
FT   TRANSMEM    263    286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    298    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    329    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    411    429       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34    262       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      271    354       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   431 AA;  49690 MW;  B120D7224F743407 CRC64;
     MLLHLLLTLL ATSPGLGDYC LEGVVADNCD NLDAIIKRLF TNYSRYERPK PRRHCEADNT
     TTDTVFVEIN FFINAISAVN IVDMDFRLDF LLRQRWYDPR LDVADRYNYS EVPIHLHMRD
     IWLPDLFFRN SKSSTPHSLT TPNTLAWITS NGMITYSQKL TLGLFCHMQL WDFPMDTQYC
     SANVGSYGYS TRDLEFRWWN EGGYDRSGRK RSGPVLNAAV QLEDSQLNEF IVINHTCTYC
     DRNYKTTGSF TCLNVAFQLS RKFGFYLIYA YLPSLLVVLI AWMSFLIDFE ATAARTSLGL
     LTVLSLITQS AAVLSQLPRV SYIKAIDIWF FTCFSFVVGA LLEFSFVNTA ARKEAKLRER
     GRLLSTDLSV VGHAENEALN RRKARKWVSV RLSSRARIYC LTARCLDRVS AIVYPLCFLL
     FNIIYWLVYL H
//
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