ID W6UEE7_ECHGR Unreviewed; 1386 AA.
AC W6UEE7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=EGR_08707 {ECO:0000313|EMBL:EUB56442.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56442.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB56442.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB56442.1}.
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DR EMBL; APAU02000116; EUB56442.1; -; Genomic_DNA.
DR STRING; 6210.W6UEE7; -.
DR EnsemblMetazoa; XM_024497956.1; XP_024347638.1; GeneID_36344422.
DR OMA; FMSSERN; -.
DR OrthoDB; 2875749at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 309..468
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 608..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1386 AA; 153751 MW; D928468DEA614A31 CRC64;
MKVSDQVSKV FFHHGLFCST RPLPTLLTVI CIFIFFCISR DVPFEAIPLP ESKCKSLLST
PSIQKISNDD FNFTFVAQII FRSAISPQHS DITHMDGLRC NLNASFRIHE IVQSTAFFVD
TKSNCSGAVG EQKLDSICMR MKDLLISLNA DTSDLATTKS PTSRILSLPT PSLPFDGCAV
LSPSLIWGNE WSLFHLDDID LSERLNLNEV QELLDVLFGL PRRHLGMFRM KFRNLPVVNA
FATTIVLRDF YPEYIHSLRE RLMEAFPDSR FVGKISKGKS QDHYPDPLGK DSEPRVFVVH
YRGHNYLVQY APAFAVYTFL VLYIWFSVSK IDMVKSKFGL AVSACFTIFA SLVMTLSLCA
TLGLMSPALR GREFFPYLVG LIGFENILAT TKAVVGTPID LPVKHRVAQG LAKEGWPMTK
NLLYAFFCTA LGFLTFDSAI QEFCLIAIIS FTTDFFLQMF FFVPVLAIDI RRMELSDLRQ
RAPLSSIPPP LGNEKTVNTG FCNHSPAVTR SRDTAPPPDY HRRSMSPIPQ NSQNLGHRRV
HSDASNAAFM SSERNTSGGG VSFRRRFWAF RTNRRVFQHF GMAIVLIWLV IFLCYTLLPS
PSPPRPTDSI NLASPHLHKP GNGAGESKTA FSETEDVSLR RLFGLRSINL HGFEVRWDAD
NLWRHMAFST WPSIADRYNF SLEGRRLVIF EPIHVVQLFS PAEAMHARRP AYEASNANAA
AFSKSRAKAT KGFSGVVLPP TAEDQEFDSD RTWWSHVLSF GHKDALRALD LPWNGFLDWT
TRLWSTATMA AASLFGAGFF LTITATVMLF VHKSNPNAYR EPVVRVRQLV VPLLQKNHSI
EEWIVAHGDG EQSGNGTISL WGDGLFHGFS GTTSTALSIS SHRSRHRGET VDNLIAATVS
GYFGGPKLIR SIRLWSADCG HLVATVDRFY PGSFEIRGAG SRHRDLSRRF SPIWSMKVLA
PTGSLVAGCA NGTIEIWDLD NFDLRQVIDL TSPEDFYNAQ GELVETGGEP TPVGGVTVIE
ASLENQHIFY FGTSLGFVGC VKWALTPSSS TPTTPTNTEP ISRGGRTNRP QWSVRAKWSA
HPRSRGVVHL TPQRVFLPHR RFTPRSLSAL DGHCLRSGGV GGCSSGGGSS REDWALVSGA
MDGSLALIQP RHFRFQRFHW DPSHLLCADF LQSTIVVGQA SGRLRMLNLT AAVPPANKDL
HVEVFELCTI SATGATATTP TAEGSLGSAS WIRLFKISTP SSTEDFRMVT YCHTGAVSVW
SIHASSCHLI RRFPANTPAF AIRAPIICVD DRVIFGERGY LRLVNPRTAK YERSVQLMPP
LLTYPTESVA KGERTMDSQA NPSAEQWERG LGPLGITGGS HGHQYLCGLS DAGKSLFIVP
KSVLLN
//
