ID W6UEW3_ECHGR Unreviewed; 747 AA.
AC W6UEW3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Forkhead box protein F1 {ECO:0000313|EMBL:EUB56657.1};
GN ORFNames=EGR_08463 {ECO:0000313|EMBL:EUB56657.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB56657.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB56657.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB56657.1}.
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DR EMBL; APAU02000107; EUB56657.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UEW3; -.
DR STRING; 6210.W6UEW3; -.
DR EnsemblMetazoa; XM_024497712.1; XP_024347853.1; GeneID_36344178.
DR OMA; WEPEAYP; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20020; FH_FOXF; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46262; FORKHEAD BOX PROTEIN BINIOU; 1.
DR PANTHER; PTHR46262:SF2; FORKHEAD BOX PROTEIN BINIOU; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 348..442
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 348..442
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..296
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 80768 MW; C755098013E9F40B CRC64;
MAMEGNYLQS HPHPNPHAYS GLADHATDLT AHGVTSHHSH GAFLLPPAPA HYHHHPQTLG
ANDGAAPPDT TLHYHHCLFS EPSVPWDTSA QQAFNHHQQQ QQQPQQPQNE SQSCSHEDFF
TEKQPDPMSV SYWSDKLPSP AFGANWEPEA YPGAYSLAPN DAPFYPEFQS SSPFPPLPGA
HSLIPQQRIS YFRGPSPSQY ALGRSVPAAP QSYSGMESSS DACLSSNNTT ESSEAVNGSG
HPQEGDVKPT LPPIEYYSDR QEFTEPLREC KEVAGRAEEV ENEEVEGEEE DGEEAEGSAV
SGDRVIQCED DAALGQEGGS KESNLNLING GDPKGSHKES SSGRRSEKPP YSYIALIAMA
IRASPNKRCT LSEIYQYLHS KYPFFRGSYT GWKNSVRHNL SLNEVFIKLP KGMGRPGKGH
YWTIDPTAEF MFQDGASRRR PRGFRRKCSL SSASAVAAAA AAAAVVPSGS QDGQVSTAPF
NQLPNPCVLM GSDVAFSQFL LPSMHISANS SSRNPSVGTP PNSSNETELR STEDERNVAG
GVFYTPSSAA VPSGGAGGSN FYNASMEHQY QNAAAFVHQH FPEEVQQPLK AESQSPHCEG
PNSLYGILSS VSTAAPVNAG VAMWSENPDA RRSLYSASNE ANAEIQHMFD SRQFSMPWKA
WEPSSGDCKP SSPQFQPPHL PTSAVESAAV ESAVASQNSS PAPLLHPHLS QSLLMQASPE
LKNTSIPCNG EFSIPLPLCV RVLVHQI
//
