ID W6UG70_ECHGR Unreviewed; 1977 AA.
AC W6UG70;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=DENN domain-containing protein 4B {ECO:0000313|EMBL:EUB57137.1};
GN ORFNames=EGR_08021 {ECO:0000313|EMBL:EUB57137.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB57137.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB57137.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB57137.1}.
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DR EMBL; APAU02000093; EUB57137.1; -; Genomic_DNA.
DR STRING; 6210.W6UG70; -.
DR EnsemblMetazoa; XM_024497270.1; XP_024348333.1; GeneID_36343736.
DR OMA; PSECPRI; -.
DR OrthoDB; 1079051at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF30; DENN DOMAIN-CONTAINING PROTEIN CRAG; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 56..214
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 206..819
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 838..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1527..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1576..1607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1977 AA; 216168 MW; 274C522DCD6E764A CRC64;
MDDVHSNGGG SKHIAEYFAV CGLSERPAPF NVSEILLNSE EIVLSESKCL DFSRYTTPII
DIQLVNMSQK EHPPDGYQLI DKSIGGSTGC FLQSRSGDDL CICYRRGYDI PPIGDIGLVD
TDQRLKPNSS NITHTIDHRP AVIMKKRFLP TSNMYLSYSR LHKNYGVDEL ALTDICVVLK
KKGERCPLGY KELPQKLIHS LMADDMYICY KKSFVKRYIA TYQPEVLMWY HVPSASSSPS
MATDEMANQP IFNTVDIATL SNFCLPWGAA IESWSVDQNP PGSVFFTFVV TNAAYKKFHG
SALTFYEPYD VSQLDRDRCY RLNVDPELVR MEEAEEEAEG GGRQQAAMVV REAEAEAELF
TQEELLSIEQ RQGVFASSRI GDRVLGVTKT LCLVSRFNFG NGLKPFLDFL HFRCFSSKDQ
SIPLERARNH GLLAPRPYKL SAGPGVVPAC LLDECDMGFK IAGISYRVVC VCVCVTFEEG
AVAELVGEAC FEQLGCGAEA EATIATVIYL LDSMQQCGRT VCKTNFFPFQ KYLAFILCEI
PFPDRRSPNI TVDLDDYHMR LQIPYGNHLS SSGEPFAHLL HRLGSELTLQ LMVQLLTEQK
LLFVSVMPDL LVDTIQQLIT LIHPLRWVLV YIPLIHMRCI HVIQSPSPYL IGVDSRFFEF
FQLPSAEADI SVVDLDTRQF RPATTTVAGV RIVLPRGPQK RLRTALIRNE ERLAELDLRM
HQEAKIGVRV QEKYKSHLSL LGANVRRACY TFMTELLQDY RKFLLPVIFK DRELLFDSEG
FVKHTADRAS NAFYATLVGT QLWADFVRDL NCISERTAEL EAFDNAIAHL SLTRYQSKTK
GGSSRGIGGS GDIEGGGGGE TCSQVSSGSG GDAGSAASAP LNGFSASPRD SLSGTDGSSL
SGRPLPPSEC PRIIGSPSGL LELDPLCSDL PLNDFTWTRR DHFPETVNTS LLDELCTRLR
HNGATAAATI PSRTMVTKME TGEEELIFRL VDDTDVMLGD GEDFCPSLHH TPPPLPFVHG
NGVPKALGVA QLNSLLKRTL QETTDCLIAA TKRRNAGGVA WAGQLLSEVY SLWFLLLPAF
IASLQQHCGR GNNGDGICLE ARHFLFHVVD VFLRLWDSPL QPVDQVYVRV LIALLYEYGT
SDQGVVSFWS SRPLNAPSYA MANQLQRDLG HKLTSSESAE DGAESGIGIS TTLSREVADP
PCLVPQALST PIQNCDASSP RHPCESQPSF SIGDDEGDGG DNGDGDGPSK SSSNFNLGNS
QLVGSMDRIS IGDGNRKTSG LLEPVEQAHF SKKGWKSFAQ ASMRKLASFR VEYVNPDVIT
LEQSPSTSPS PQPSQHLRSR SVSTTANKSI GYFSLFGQPG NGTRLPRNMR PWAVAPISAS
VSSITTAASG TVSVPVNSSV SADEALRQGA DATQMSLQSS TSSSLWFQLL QRHLSVSAMS
PTPSRRAETS DTPRGSITSN EEGVVNTTVA ASPLAFSFDS QLAVLSYQPT SWYTIAGPLA
VGSVGDRVCL ANPLVMKLSP SSLQSSATAP AYAAMRRHRS RSSSLVRARR DVGLKHSPSA
SFPLLSLTSE ELVQALARSE SPRSSKPPPA LRRPPSTTTR PSTGPVTVSR VQELRVIFNT
CTPCASCSRL FYDEEIMAMW VAAGDPPYTG LSCSSCRHSL MPRLIVRTIA ILEITPSTNA
ATTPLSHGLI ELSVPFLSPL VLRRQLEAVV DSGVGGGSGS SKGCTESMAV QALSSAGLLG
HRRGRVLLWN LVYLLHRAGL PTHLLDAYPA WLMDAQAEAR RLGGGRRVLL GGSLTIARAL
SEVTLSPDLP VCLVARWVAF PRKTAAGKEA PMLYRLWDNT HPACCLSPSS SVADLTAPPG
RGEERQECAL EEIVQMAGDA LTYENVGGAI SAVRSLKRTA IQSVHRELLL LYARIHGTSW
QQLNKFDAGY IAYLLDEMQQ AGVQQQEQLQ RWRANDEMPP SATALACRCI FRNLTLT
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