ID W6UHS4_ECHGR Unreviewed; 405 AA.
AC W6UHS4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Protocadherin-12 {ECO:0000313|EMBL:EUB60616.1};
GN ORFNames=EGR_04449 {ECO:0000313|EMBL:EUB60616.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB60616.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB60616.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB60616.1}.
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DR EMBL; APAU02000028; EUB60616.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UHS4; -.
DR STRING; 6210.W6UHS4; -.
DR EnsemblMetazoa; XM_024493698.1; XP_024351812.1; GeneID_36340164.
DR OMA; WHENSLL; -.
DR OrthoDB; 2999121at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 3.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF310; STARRY NIGHT; 1.
DR Pfam; PF00028; Cadherin; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 2.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..405
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004882809"
FT DOMAIN 24..153
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 188..282
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 304..380
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 405 AA; 44949 MW; CA6D2441BE613337 CRC64;
MLPSSLLLLL LCLLHCQASI AFPSPFASTF DVVEESPPGS MIPGVADYLK RIVLLRVEMP
NSTTFQLMGT DALTKSFVIN EKSGELRTMG RIDRETLCSS EVDPRSDLAT DSNCLKPLNV
LIKSLGIGGA SGSNMREKIM LRILDINDNA PRWPGKRLLT VKFVEAFQSL SMYGKQEMTT
QSQLLDRAID PDSGPNGTVS YSLKGTGADM FRLEYADHEN GRFVHPDVNS PLRLKPVVPL
DREIFEFYNL TLFAYDSGNP QRSSSIPLHV YITDVNDHVP VFHSYVPGHV SAYPRESKQG
ELVKYVPERG HLMETARIGS VVLQLNATDE DAGDNARITY SIFPSDAAFV QTYFALDPIT
GYLTVKQRLD YDSGPRRFTF KGEVGLEGGL GVVVTRLSEP KWKVF
//
