ID   W6UIR9_ECHGR            Unreviewed;       709 AA.
AC   W6UIR9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=COP9 signalosome complex subunit 2 {ECO:0000256|ARBA:ARBA00014879};
GN   ORFNames=EGR_04079 {ECO:0000313|EMBL:EUB61046.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB61046.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB61046.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CSN2 family.
CC       {ECO:0000256|ARBA:ARBA00009318}.
CC   -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC       {ECO:0000256|ARBA:ARBA00007756}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB61046.1}.
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DR   EMBL; APAU02000024; EUB61046.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6UIR9; -.
DR   STRING; 6210.W6UIR9; -.
DR   EnsemblMetazoa; XM_024493328.1; XP_024352242.1; GeneID_36339794.
DR   OrthoDB; 5477605at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.570; -; 1.
DR   Gene3D; 3.30.450.190; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR006762; Gtr1_RagA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10678; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR10678:SF3; COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF04670; Gtr1_RagA; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00753; PAM; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT   DOMAIN          514..676
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|PROSITE:PS50250"
SQ   SEQUENCE   709 AA;  81203 MW;  252A85656DE46B52 CRC64;
     MESYFATQRE NIFRNVEVLI YVFDVESQDS KKDMAYYRSC LEAINEHSPG AKIFCLVHKM
     DLVSEPKRSA VLTERERQLI AATRPDQCVC FGTSIWDETL YKAWSRIVYQ MVPNVQALEK
     NLIQLCDVLE ADEIILFERS TFLEIACHTT KEHPDPHRFD KISTIIKQFK LSCSKAGANF
     TAIELQTPNF SAFIDVFTPN TYVMVIMSDP TIEYLLGFSL LCYPSQHPKR QEVLRETGKG
     GDTSLGYQRK YTGTLSLAMS FNDDDMFIDD VELSVAYSSD DNSEPDVDLE NQYYNAKSRK
     DDNPDAAIEE FKKVLAIEAE GGAKGDWGFR ALKQMIKLKF RLGRLDDMME DYRTLLTYIK
     TAVTRNNSEK SINSILDYVS TSKQMDLLQT FYNTTLNALK DAKNERLWFK TNTKLGKLFL
     EQGDYVQLQR IIRELRESCQ TDEGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ
     SLQIKSAIPH PMIMGIIREC GGKMHLRVGE YQRAHTDFFE AFKNYDESGS PRRTQCLKYL
     VLASMLSKSG INPFDSPETK PYKMDPQIVA VTSLVTAYQN NDVKGFERIL REQRESIMSD
     DFIREHIEDL LHNIRTQVLV KLLRPYTRIR LPFISRQLDL EPREVEALLV ACILDGTIAG
     RIDQAAEVLI LSPPNPSSVE ARYEAINRLA SSLSALMNVI VMQAGITTS
//