ID W6ULH9_ECHGR Unreviewed; 665 AA.
AC W6ULH9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Fibrillin-3 {ECO:0000313|EMBL:EUB61976.1};
GN ORFNames=EGR_03249 {ECO:0000313|EMBL:EUB61976.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB61976.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB61976.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB61976.1}.
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DR EMBL; APAU02000016; EUB61976.1; -; Genomic_DNA.
DR AlphaFoldDB; W6ULH9; -.
DR STRING; 6210.W6ULH9; -.
DR EnsemblMetazoa; XM_024492498.1; XP_024353172.1; GeneID_36338964.
DR OMA; CKNGECH; -.
DR OrthoDB; 2995099at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 1.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 2.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57581; TB module/8-cys domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51364; TB; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..665
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004882219"
FT DOMAIN 137..187
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 202..242
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 244..287
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 292..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 665 AA; 73870 MW; 01F4F0437DDCBEA8 CRC64;
MQVTFGVRIL LPLLVVFLSS PRLCDAYSSG RGPNVCGTFY GLTLCCKGWT KSLDGLCTTA
ICDGNCGERG SCIAPNQCRC EDGRVQDDCL MEDDNGYLAD EPVRCPSNCN NQGRCINGKC
VCDFGFKGSA CDEEEVGPCF IQTERGVCKN KVTGPGNETA MMTRNACCGS IGVAWGGLCQ
RCSAQSSYCG KGYIRLNHQC VDTNECEIPN VCMGGICRNT DGSFECDCPY GYVYDKNTVQ
CRPILDGCQK NPKACTPGGR CIPLHGTAYI CQCDSGYVAT DGNTRCRKEE VALNYCEIFE
GRLCKNGECH PTASSYECTC NPGYVPSRFK KQCIKEFNAC TFYGNSVCTN GQCLPVDRSF
RCICNPGYVL SGDGTACLDK CQQLGPSVCQ NGFCVPRPYG DYECRCHYGY QPSPDRKSCL
MQLNPFQTSK REPLSSGNIY RGSYQADWPQ ENRAYHNVKP QLGETRWQPS SRVKYPNPCA
DSTVRRKCMG GFCINLGRGS YECRCYKGYR AVNGNQQCVA DYGRTNLAKE RTSPIATLRL
QNSSYVSPFI SPNPIHSKCR KLSSPALVIC IAERQDSVHL EMWHCFPYPL RRTHEQTHPQ
LYHFQPPSRC CLLLIPHFCL YSTKWTRESN LCIQYVLLTL PSSITALILP NFSLKYLGLL
VCLKD
//
