ID   W6UME3_ECHGR            Unreviewed;      1042 AA.
AC   W6UME3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=5'-3' exoribonuclease 2 {ECO:0000313|EMBL:EUB59297.1};
GN   ORFNames=EGR_05781 {ECO:0000313|EMBL:EUB59297.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59297.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB59297.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB59297.1}.
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DR   EMBL; APAU02000046; EUB59297.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6UME3; -.
DR   STRING; 6210.W6UME3; -.
DR   EnsemblMetazoa; XM_024495030.1; XP_024350493.1; GeneID_36341496.
DR   OMA; CLHYYVH; -.
DR   OrthoDB; 167745at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 3.40.50.12390; -; 2.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   PANTHER; PTHR12341:SF77; 5'-3' EXORIBONUCLEASE 2; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF17846; XRN_M; 2.
DR   Pfam; PF03159; XRN_N; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT   DOMAIN          1..257
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          324..421
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          535..860
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   REGION          488..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          858..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          974..997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..526
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        885..903
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1042 AA;  118572 MW;  392D5DBA14FBAD24 CRC64;
     MGVPAFFRWL SQKYPSIVAH CVEKRGRVID EEGHREPVDI LGPNPNGEEF DNLYLDMNGI
     IHPCTHPENK PPPKTEAEMF VAIFEHIDRI FAIVRPRRLL YMAIDGVAPR AKMNQQRSRR
     FRAAKESHDK ELTVERLRSE LMAKGARLPP PKSAAEHFDS NCITPGTPFM ERLALVLQYY
     VYERLNSHPA WREIQVILSD SNAPGEGEHK IMDFIRRQRQ APTHDPNTRH CLCGADADLI
     MLGLATHEPH FTIIREEFKP NQPKPCDLCG QYGHDMEDCV GAPSENFDRP PPPPGTDMEF
     IFIKLAVLRQ YLEMELRMPN LPFQWDLERA IDDWVFMCFF VGNDFLPHLP SLEIREGAID
     RLIDLYKLAV CDVGGWLTDS GRVNLDRVQL IMTELGKVED EIFKSRREEE LALRERRKRQ
     KLGDGGRHYW DAPLSGILTP APIGEKPRFG SVNAKEMHDA RRHRQPNVKW VEQCLQNQEA
     AVSLRAMLKS STSPPPSRKT KAPPSNDEGE DEGGPSLPKR PRRGRLGGVD ASVIKTRQVE
     EGADGETLDE DERADRCDEV RLWEEGWRTR YYQSKFGVDP ADAPEFCIKV AHEYVIGLCW
     VLAYYYQGCA SWDWYYPYHY APFASDFVNV VSVETGFAKK RTKPFRPLEQ LMGVFPAASR
     SHVPPAWQDL MTDPDSPIID FYPTDFKVDL NGKRYLWMGV ALLPFVDEVR LLKALDERRG
     QLTDEERHRN LRRPGLYFVH ADTPIGQTIT ALYDPSSVEL AAERVKKLKG SSGGEYDGIA
     PPEATLINAA LTQGIAGHVW PDRKGVCLPG RRMPSGVPGL LPDIPAVQQH AVSAYFENPP
     YPFGYVFPTR LLDSVKMPPR CQLLPPTSRG RGRGRGGRSI NGGNPRFDGF SNGNNNAWGG
     GTSWRADQTP AERMIHRALP DCNEFYAPRQ RLNPTQRFHP YDRQQQHQRA PTYPPAYPPP
     SLMGPFANPY TAYPHPDDEL DWNRRGGSRS GRPPSYRGGS GVWWKRLDLE LRPKVAQAPS
     SICRLGLRMR SDSKKYRQEY PD
//