ID W6UMT9_ECHGR Unreviewed; 1164 AA.
AC W6UMT9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Glutamate receptor 3 {ECO:0000313|EMBL:EUB59432.1};
GN ORFNames=EGR_05683 {ECO:0000313|EMBL:EUB59432.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59432.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB59432.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB59432.1}.
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DR EMBL; APAU02000044; EUB59432.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UMT9; -.
DR STRING; 6210.W6UMT9; -.
DR EnsemblMetazoa; XM_024494932.1; XP_024350628.1; GeneID_36341398.
DR OMA; LFMERDT; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF600; GLUTAMATE RECEPTOR 1-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 2.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EUB59432.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1164
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004882903"
FT TRANSMEM 726..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 992..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 567..966
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 577..671
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 517..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 128580 MW; 2891FD33FE065C0D CRC64;
MYCFSQLILT SSHLLILPVG QPIPIEGSLV FIPLTNSQCA RKVVSHNELD MKIFIPITIT
LSALCLARAD RRQEVPIAGI FEAGSVGESA FSFAVYAYNK NSHNPFYLLP KLSILTPPHD
ALRVMDRFCD LVSDNVLAVF VSELAFDEEV NRVLTNTAAA LQIPLITTAD GRGGVFTRNL
MPTTKEALAE VLVHENWTAF AYLTTSMEGV RRLGQLVGEL KERGSNLSLT EVTVHYVGVR
GMNERELQGS LVALDGALKK RVTRRVVVDS RVVETNQLMR MFSRMGMNRG EYEFLFASLN
VADTDLVDYI YSGVKLAGYR LMDPERADVK QFAAEWTNWN SRSSTVPHLP PIASTTTTNS
PPFYHAALMA DAVGLFTSTL HCRLQQMEPH RANASLAELT AAALQMRQQP SLSGGSSKRN
GGGRSSCYLG GRLMYQHGAY QVRGLGVIAD LRRHFVTVDV DDGCGDIGLR GLTGDLRTSV
EEREARELVL WSAMDTVGLQ PVARWSSTTH LDFEAFKPPH ITKDPHTTPE PSGDSTGSER
LPQVWEEDFD PSVVIDRQRL ADYHNRTIRV VTIWSKPFVQ PKPRKLGAPE AHGIDGFEGF
CVDLLEEISK IVGFKYDIHI VYDGIFGTKI GEMPPQRVEV LSRRSLSNLV DRRVETRRLQ
VWNGLIGEIL NNTADLVMAP LTVNYLRAQV VEFSEPFLAF GLSLIIKKPG KQKSGSLSFL
RPLSNAVWFA VFGAWITVSL GLYVIARISP TEWQVTTDPV TGRRHCNRRF TLGNSVWISF
AAFVQQGVDF SPRAPGTRIV IAVWWFVTLI LIAFYTANLA AFLTISLRVP PINSWNDLLK
SDMEYGSLKS GSTRDFFFNT KLEPFAQLGA WMKRNAHALA NNLEEGVDRV RSSKGKYAFV
LESVMNEYVN NREPCDTMMA GSAFGNYGYG IALPRRSPMR EVLSDAVLRL RESQVLANLR
KKWWIERGQC SSAADTDRSA ADALALINVA GVFHILVGGL LLALLVAAVE LVWHMQWKQR
GRWWRQRSKV AEVIGKSTKL GAEARMGGNE VDPWTMQMHN DNNNNNKDSR AGYGLEATRS
TATEATTSTT ATTTMETAMT PTATAPTAPT MIVETTTATA STRAPIVIEG ATAGPATDGG
TAGMGKKVVN IFGAEVFNHP LGEN
//
