ID W6UNK1_ECHGR Unreviewed; 994 AA.
AC W6UNK1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Basement membrane-specific heparan sulfate proteoglycan core protein {ECO:0000313|EMBL:EUB62793.1};
GN ORFNames=EGR_02234 {ECO:0000313|EMBL:EUB62793.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB62793.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB62793.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB62793.1}.
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DR EMBL; APAU02000010; EUB62793.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UNK1; -.
DR STRING; 6210.W6UNK1; -.
DR EnsemblMetazoa; XM_024491483.1; XP_024353989.1; GeneID_36337949.
DR OMA; DETTCDY; -.
DR OrthoDB; 2996945at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF66; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00192; LDLa; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 893..985
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 177..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 184..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 311..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 318..336
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 487..499
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 494..512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 621..633
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 628..646
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 764..776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 771..789
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 829..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 875..890
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 994 AA; 110880 MW; E7114C11096FDC62 CRC64;
MSKGPKYRFN KTASTAKSEQ VFPSSNLGHP KPPLIIDPRM VDMPAWQMFE FVCSSTDGSR
VEAYFSPDDG RVGEDPRFRV KPIRHPIFVD PPHIYKPAWV AFEFVCRSST GSPIAAIFVG
DGSRVELDPR FTVTTYNTST IIVKAPRGLR DIDDLTIQCV LPTGQKKNVT ITIASSCGEG
YTQCDDGNCI PQTKLCDGIA QCPDHSDEDK AFCKTLLRPP VIVTPPVVEA PAWKPFQFTC
VSTDGSQMNA VFKADGSSVY LDPRFRITRY NISALRITAP EGLRDKEDVE IECVTPTGQR
SDVSITIFDE CERNYTKCKD GACIPETQLC DGTAQCRDRS DENPLFCKGF TCLLITKPLL
TITIVRISAT RYDPPLDIVR ICEVFVCISG VSQRLVTVQL CYIRHPPWVP FSFVCVFPVG
QKPDIIFADD KRSVQRDPRF TVRRVNSSSV EVTATRGLRG DQETILLECV TDGGLRGNVT
ILIDDMCKPG SMQCRNGRCR PIAEFCDGKS DCTDESDELK EFCDVKVPNL VLTPSRVVAQ
PWRQFRTVCV SPSGSQPTFV FSKNQSPVER DQRYLIRHIN ATSVELAAPL GLRGQEDVDE
IKCTNAVGES VDFEVVIVSP CRAGQMTCQD GTCFPASWFC DGRYDCYDKS DERRDFCPEP
TRTPSPRPTG VRFSPSKQRV RPGQEIRLEC SALSSDVLQH PIVEFANGTS VTVDPQFRVE
YPQPGRSVVT IPRGAEVSQR HMEFQCYLPW SDKSRAEVFV DQVCAAGQRR CDDGHCIYLG
QFCDGRRDCA DGSDELPHNC DACDPISRPC GVVNGEEPKV PYFQEHWRCD GENDCGNGFD
ELNCENYTRV PGQRCGSPRY DCSSDGSQVP LAYQCDGQPD CLNGEDEMNC MRPTIYSEGW
VSRYEVRRGQ DLVIECEVLG VPPPAIIWRF NWGCLPQSVR TRVEPVSSRF GCTGSRSRLT
IRNVQEGDDG IYNCEGITGV DRALSQDIFV ILVD
//
