ID   W6UQ08_ECHGR            Unreviewed;      1282 AA.
AC   W6UQ08;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Histone deacetylase {ECO:0000313|EMBL:EUB63750.1};
GN   ORFNames=EGR_01373 {ECO:0000313|EMBL:EUB63750.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB63750.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB63750.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB63750.1}.
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DR   EMBL; APAU02000005; EUB63750.1; -; Genomic_DNA.
DR   STRING; 6210.W6UQ08; -.
DR   EnsemblMetazoa; XM_024490622.1; XP_024354946.1; GeneID_36337088.
DR   OMA; MMCTAGQ; -.
DR   OrthoDB; 124800at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF15; HISTONE DEACETYLASE; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT   DOMAIN          720..870
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   DOMAIN          910..1080
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          487..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..506
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1282 AA;  137553 MW;  1A3981B41403B2AA CRC64;
     MERIPDALCQ QPAGKYEPSS ARQPLTHKQF SQEYERSSSL SELIAPKQHQ KEVLEAAIGA
     SVPVDRDLAS KITVTSLKSG NSIYDRVAAA LNHSEDLPAQ ILGLTPDHRR HSAFASTTTN
     VTAPIDHIKS TSGSSRQSSG SSYTGSVGKQ QTMIAAATPS GSISTVATTI SKSHVSTHVR
     QRLKDCVLNK RRSKESAITG SKTASFVSPS MELDEDWGPP TTGCSNYRDY HPTDSECGFP
     SGYGIPQMMC TAGQVATGQQ SAFLADTRKH MGNLPPWAFI ALSAGQEIRS NNDTSLVTPR
     NTSVLLRKTL SEPSLKIRGS SGALKHKTNR NDRRSVNPLA VAAAVVSSAP YFAHHTRGSR
     SISEAGDVGQ CLGLHKASSR PLPTHSQLTL ENKELSKHSE ESDSTPMEVA SEADSHAATT
     SMKFGTVDVD MSETRGTMSN SPKCIDDSEA VMEFLASLAT NPVAMTGGLL KAIQNYLCLV
     REYMKQEKSK NSQGGSPKNT DQSVGLSGES AELCEFGRGR QQSGQAPYRR CKQVSGLLSR
     TRSAPIRLTG NVVRGNFGGP TSCEGGSGGS LIDSGGASGV GVGLLSAASA MAMEAAALTS
     TSTLKSFTKT VTSAGLPEDE QRSKIMQQLR RKLLEKSESP NSERSSGSST LGNVCDPFYL
     KGGHQNASPL LERTASSPVV TLARRPTTET PAQSTEFTTV LAYDVGMLAH RCTCQIDANH
     PENPSRLVAI WQRIQSSGLA AECQHQPGRR AALTELQLAH RDVYTVLFGS NPASRSRIDP
     SLLATVRLCR LPCGGIGVDS DTAWHTAGHT AHAARLAAGC VIDLACRIIL HQAPNGFALV
     RPPGHHAEPG QAMGFCYFNS VAVAARRAQL VRAIFPLEEG GSGVPNLSTS PSTNVYNSCG
     LPVVKKSGTI KRTNEHLQIT RILIIDWDVH HGNGTQTVFY PDPTVLYISL HRYDDGAFFP
     GTGALEEIGE GMGVGFTVNI AWPSGITMAD AEYLAAFRYI VLPIAREFKP DMILVSCGFD
     AAPGHPANLG GYNVSPAAFG WMTRLLTNQD IAGGRLALCL EGGYELNSLC DCTEACIRAL
     LRSTYERTTG LQDAPLLYRL SDQERTRKPH PAALETLKQV SRFHTPYWKS LSAIEITGTP
     ADVWLPSGEE EECSFLSAIT KFTSEQCKHS LGKLDSKNKP NSWPETELII SVGTNSQQIN
     QRKFVKQACL EEDDISTALE DVPLDMTAKS MRLPSHEMCS QAVSKMEADV NTAPVESTDL
     ITAAALVGLA DLHVTPQTAK HF
//