ID W6US12_ECHGR Unreviewed; 819 AA.
AC W6US12;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Protein arginine N-methyltransferase {ECO:0000313|EMBL:EUB64460.1};
GN ORFNames=EGR_00410 {ECO:0000313|EMBL:EUB64460.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB64460.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB64460.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB64460.1}.
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DR EMBL; APAU02000002; EUB64460.1; -; Genomic_DNA.
DR AlphaFoldDB; W6US12; -.
DR STRING; 6210.W6US12; -.
DR EnsemblMetazoa; XM_024489659.1; XP_024355656.1; GeneID_36336125.
DR OMA; TDVHALM; -.
DR OrthoDB; 1022106at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015,
KW ECO:0000313|EMBL:EUB64460.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015,
KW ECO:0000313|EMBL:EUB64460.1}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 53..175
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 311..415
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 819 AA; 91230 MW; B7EEC24AB0B682D1 CRC64;
MDNMNFCVER GKGRGSLLRL NQMKDVKVSD NFGEIFWSLS FGIAFAVVCV VHKMPIDLIL
NADGNSVCAD CKSTCVLGLS TDYSVFICKE CTETHVKLGG GWRSLASLSS STEAELKILL
PGNGNRQVNE ELEAELPTYY RRPWPGPTCP AFFREAFVHC KYIVRAFSKG AGAQGLQVGF
SNSTKSGQLL KKLRDAAQFA PRLFEINSTT NTFKYFVKLT DTEPKECIDV ERCNMTFVDC
EAFGVPPNTA LIQFVQDHST RHIFVRSEDS HEILNWYNTL RLCKYQRLRL HLSGTGQKVS
MDEIVSYLTS DLGKFGWLLK SGPDASYAFR RRWVMLTKRW LLYTSTPQSA FAKGEIFIGA
SGDGYSVQGK PPKSWKKVPT DFPITLNTPD RSFVFCAASE EERGYWLNAI SAIIERPVTL
LEAKEAAPAL TRKRSKIDDD DHEALSKNKG ASSTSDDELY FRSYSFTDVH ALMLSDKVRT
LTYQLALTRA RRRLEGGVLL DVGCGTGILS MFGAKAGAAH VYALDGVAKL CHLARQIIAE
NNFSSRITVI NSKVEDAQLG VDRVDAIVSE WMGHALLYEN MLPSLLSARD RYLLPPHTST
VDLASWRRER LFPCRASIFI AAFSAAAVNG DTGGYDEEEQ EQEVEEEDPV ENVKQWEELS
ELYGVNLTGA FASAVQQDLE RRVHVDMIDA RCVVTTTSEV ATLDLATLSL EELSTHGVKG
TFEVKSMGTV SVRGFVIWFS VQFPHGDVLS TSPYKASTHW QQSLLYLSGP LPLEQDEVLS
GEVHFTHPED APRDLSISID FSVNNSHETR VKANYLLSS
//
