ID W6USA2_ECHGR Unreviewed; 1927 AA.
AC W6USA2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN ORFNames=EGR_00692 {ECO:0000313|EMBL:EUB64148.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB64148.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB64148.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB64148.1}.
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DR EMBL; APAU02000003; EUB64148.1; -; Genomic_DNA.
DR STRING; 6210.W6USA2; -.
DR EnsemblMetazoa; XM_024489941.1; XP_024355344.1; GeneID_36336407.
DR OMA; ECSPMWI; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:EUB64148.1};
KW Ion transport {ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132}; Transport {ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 751..774
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 808..832
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 853..886
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 946..968
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1170..1188
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1209..1227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1311..1336
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1435..1459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1522..1540
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1552..1570
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1636..1669
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1727..1751
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 204..475
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 755..975
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1168..1468
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1518..1764
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1927 AA; 221340 MW; 7CCC60FE1443A429 CRC64;
MDANFNGIDM QPTEECPNPL PQGFVLPQFI PLTPESVRLS LQRYQRQKRR EQKAKELQKE
QKRKRKEWRK NKANYDSDKS DPESASFVRP ALNPVEEGLL DSTSEEEEEK DLPEVPSRAN
PMLATGKKLI PPLAKKFCAK RYTGKPLQEM DDFYRYKRSF VVISSDRTIH RLSLSPALFI
FGPFSSIRRV AIYIMVHPYP FQMVTFTVFY TCEAIIRVVG CGLIRNEFAY LRDAWNWLDF
IVITLAYLMF VVPFLGNLSA LRSLRVLRAL KTVTAVPGLK TIIGALMDAV MHLRDVAVLT
LFMLSIFALI GVQLYRGTLL RKCVVPWPGF NTTVGGALLS QIATDVYYNK SFDPYLTTEI
KSIFNGTFLI NWMSPHMVCR NLTEDGNSTC PMDFICKQTR TGNPNFGYTN FDNFESALLC
SFRLITQDYW ESLYQLVLRA NGPTHVFFFG MVIFLGSFYL LNIILAIVSM SYEQVCKQDM
ESDAQLAAAI ELCAEDGDQE AKDSGEPEKG LPMVNGCGFH FPSALRRHSI ATTDVYAQLT
LLRRWKSDDV LFNHRKRDSP RIWDNAVLFV DELSMESVSH CKELISLTSL SKKNCVSLVS
AELSTVSGAS CLSRQTNPNG LSNGNPNALE MDPEQGRLPF NVPHFALPLK EKSVYRNHTN
YSSSRFKRCA KDKSDMPSHN KSDKSHQNLK KCLCSCLFGQ RRELLEHPEC CKELSLPARI
CQYITTQIEP VLCGWTCCPC YDIFRRYIGY IILDPFVELF ITICIVLNTL FMAIDQPEKG
ETLAAVLRIA NYASLQDYKE YFADSWNIFD FAIVVFSLVE IPLTTIRGLS ILRAFRLLRV
FKLAKSWQTM KLLFSIVAMT LNALGNLTAV LMISIFVFAV LGMSLFGESY HQFTNVTRFP
ERCGKIPRWN FCDFTHSFMI VFRVLCGEWI ESMWDCLEVN GWSCTIFFLM TMVLGNLVVL
SLFLALLLSS FSAESFQKEE EAGDHNKLQA AFDRIYRFAV WMKLNIQKVF TPRRRRCCCR
SGSKNMNHIE YGTQLNHLKS AASKDIEEID VVLQNPITLQ DSLAALIPES TPTTPFFSSP
GTPDRKTSSF PMDIQEIDAT DGKTEEADDV EEILEAESVD MAFWEHPEDC CAPWIWNQIG
PLFKSCLDSK MGSVWRRLRQ VCYYIVENRY FESFIFIMII ISSGTLALED KNLPSRPRLK
MALDYMDKLF TFIFLMEIIL KWFAYGLRKF FSDAWCWLDF TIVTANKEEQ GFRKWLDALS
YKAYFRIAVT SMILSYGKED GKSSMNSFKA MRTLRALRPL RALSRWEGMR IVVNALLQAI
PSICNVVLVC FVFWLICSIM GMQLFGGKFR KCVSEATGER LPADQYPNRT VCELHKKLYK
NVSWDNSKIN FDNVPNGFLA LLQVATFKGW IEIMSDAVDI TDYDQQPVYN NATSYYLFFV
LFIIVGSFFT LNLFIGVIIQ NFNMQKKKVG GSLELFMTED QKKYYHAMKK MVRRTPQKPI
PKPKFWMSKW IFKVISNRNF DLFILGMIGL NTLIMCFEHH HQPEWMKQTM EIVNKMFIII
FTCEFILKLI GQRWYYFKDP WNIFDCCIVI FSLVCWGLED LMTTLPVPPT TIRIVRLFRV
GRVLRLVKSA RGIRTLLFAL IVSLPALFNV ALLLFLTAFV YSIVGMSFFG KVAYYAGIDA
EFNFETFPQA FIILLQISTS AGWSSVFEGL SNTDPAYCSQ EEGTCGSFLW ATLFLVSYLV
ISFMVIINMY IAVILENFSQ ATEDVQQGLT QDEFDAFYEV WELYDVHALG FIELQHLEEF
VERIGPPLGI PRPNRIRLAC LSVQICSQDR IFCMDLLDAL TRNFLGRLTT EHPETLVEQV
EVGSSQNQDG TIDRINFVAK AAKEPAVPIS NTYERQRERM AAYKILYFWR SRRKSSESCV
RVEETDS
//
