ID   W6USZ8_ECHGR            Unreviewed;      1045 AA.
AC   W6USZ8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Leucine-rich repeat and transmembrane domain-containing protein 2 {ECO:0000313|EMBL:EUB61442.1};
GN   ORFNames=EGR_03732 {ECO:0000313|EMBL:EUB61442.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB61442.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB61442.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB61442.1}.
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DR   EMBL; APAU02000020; EUB61442.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6USZ8; -.
DR   STRING; 6210.W6USZ8; -.
DR   EnsemblMetazoa; XM_024492981.1; XP_024352638.1; GeneID_36339447.
DR   OrthoDB; 2944215at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 2.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:EUB61442.1};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        805..831
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1023..1045
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  118601 MW;  574A93483DFEFABC CRC64;
     MCALGKPTNA MNQRLGIVLL ITNSLLLFIL PLVVVPLNTS RQHFTLWNLH GAQNFYPCQF
     IRASSDSDNV DTIECDRKAS AILGNSIPTI YPEGRVVKEI RIFAERQLSR ISRKAFERAG
     ANLQKLVIEG GEIRVIRREA LLGLTELQVL EIRNAQSVEK RWSNNGLAGR LFTADGELKY
     LKKLKRLVLE NVDLSDGLVA YAFYDISRHL TEVEMIGNNL VTINPYTFEK SECCKSLRRL
     RLERQNGYLN WLNNAYRWAR DLGGITLLSL SGNNMTNKTL DFGYSLNSKL RALKIENCSL
     IELSENLLSN FKALEEIYAG ENSFTIISDQ EATETLRGLR RFTNLSKLSL HGNRGLIYKQ
     PTWFRASNIK ELDYTKSLLR RIGARELPKG LQQLHLESTF LEEIDPEWAA GMTSFSHLYL
     NASYLKTVKI NGVEGNWQAA LEALKDQLKV LGLSRCQIIG QSLQLNMDDE FQITGLRLGL
     NQLQRLEHLD LSGNYITHIP QDAFQNLSQL ISLNLSNNHL QTLLILKHDV IRSTSSPSIQ
     DLDLTNNALS TVLRSPPSLG FNTSLQNLLA DGAKVKLRGN PLICDCRLRW LAGKRIRVDN
     FTCTGKNSIA GSGFQRVTVE DLENGNNCME RDFIGMPDST YPFRPVRVFG YDRNLEKVYF
     AVKGRTLKSA WSNIARTAPQ HPAFALQKVL AKLSNMTPEI ISSLQESYLV FEVAYWPVGQ
     MKELQGPLEW QVVEEGLMRT EGREYIFSVQ PIDVKRAHTI CFRNALERRN TASSTLCQIF
     QPSELTMTAS ANVSVNRMDH VHAPLWFVIL ATAGAVIFIT CILWLCVRYI CCRRKRIERR
     QKRETSFTMA SNEPLRYTDY ELQKESTYDK LENYCMENSL PNLNTVDGRP ELPKRAKRYR
     TLTQPLQTGT GSLGDLTGMQ CYVRTKVQTH QSLVTRRLNE RNSTAKLLLA GPKLPRPITY
     QHPKIVPTQL LIDENGYVRM NVESDEHFET GPEKRIRRQE ENDEKMIDSY TLGVSRGALM
     RQKSAPAYAS TASTPGAWTS PEPPL
//