ID   W6UYT4_ECHGR            Unreviewed;      1112 AA.
AC   W6UYT4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=U3 small nucleolar RNA-associated protein {ECO:0000313|EMBL:EUB63827.1};
GN   ORFNames=EGR_01450 {ECO:0000313|EMBL:EUB63827.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB63827.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB63827.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB63827.1}.
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DR   EMBL; APAU02000005; EUB63827.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6UYT4; -.
DR   STRING; 6210.W6UYT4; -.
DR   EnsemblMetazoa; XM_024490699.1; XP_024355023.1; GeneID_36337165.
DR   OrthoDB; 12287at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR045161; Utp18.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR18359:SF0; U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR   PANTHER; PTHR18359; WD-REPEAT PROTEIN-RELATED; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   TRANSMEM        554..579
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        752..772
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          715..779
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
SQ   SEQUENCE   1112 AA;  125110 MW;  BFB62F8FA00BDDE4 CRC64;
     MTSGSPSKED PEFEIVKRPK EPKLVEFSLE VPRNEEDILL SPAWVDQENA DNHRNTSVVG
     QPAVLDIHTH LNRKRKRRAS ESAASDTVSA EKLYAVIREN NRGSLDADVP MRRLSDANME
     RLSCGHLTSV EFNRTHPIVM TTSVDTTMAL FSLGKSESRL LADYVFEKFP ISSAKFTSTG
     EKVVLTGERN YFKVYDLISN KESHPAVPLG TRYGERINSV QMSPTSEVAA FSGTGGIYLV
     DLRSFEKTTT ARVSGTAVSH CFSQHGDILN AFSSDGSVFV FDLRHNARPM HRWNDYSCTG
     GCSFATSADS KYIACGSESG YVNVYAWEAV MNDATRCPKP LKSVGNLTTA VDQLLFHPSN
     QMLYMASSLQ SAAARLYDLG GQRVCSNFPT CMGRLGVPTA VGFSPYGGYL VVGQASGHAA
     LYHFDWRNSN ACADPRVHGV EQLESMESDN KQLKNESSLP MDLKATYILQ PGLIIESPCR
     LKKEKIMPKS RKPWLLSRVC ETIEGAGLLI GVVPTSAVTL RKPPTTVLEK ETYSAELYKH
     RRRLKEIRAG FKRFLAFLFS QIGLSLLVIG YTIIGGMIFR AVELENEKMV KIKGKELRTA
     LADQFSGEII RELRYQISSL NTWQGKYYTP SLMNEKSSKK TIGARKNAIK NKARRRRGLG
     SHTESEFARL RQWLHVIAYT LRHKTRQELH RSLRKLVKMM DHEGWNGEDS MDDLKWSWEG
     SILFAVTVIT TIGELLGLHL DCYGHAVPKT NAGKVLTIIY ALVGIPLVFL YLTNIGDYLA
     SLFRTLYTKV CQRCCEGTCV NKTETHRKVS IFNALRAQPS EIDLTQRRDF LLDESLHRSN
     INIIRRIGSL SVRRDKARNV KKEDHMVDCV GINVFCNEHA IDVDRKEQME QKRQGEIKGI
     DAPPSESYRM CLKVTANPSQ PFLLNTTNVK TECARKCALQ TPPLYAASLQ QVESETLQEL
     VDRCDFRAPK SAANSPKKTW KNFSYTCGTQ IPRKSMNGQC LVKPIGADAS TLSPHNVGTQ
     TALHAGPDDA LTYRSLCKSF VTGQYFRSYR REMRHERKQM QRRLKIQSHG ASARFQSFFM
     EIIAELQGVT TLNRCRFATL EDNCRAQFSW FR
//