ID W6V088_ECHGR Unreviewed; 815 AA.
AC W6V088;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Potassium voltage-gated channel protein Shaker {ECO:0000313|EMBL:EUB59384.1};
GN ORFNames=EGR_05738 {ECO:0000313|EMBL:EUB59384.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59384.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB59384.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB59384.1}.
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DR EMBL; APAU02000045; EUB59384.1; -; Genomic_DNA.
DR AlphaFoldDB; W6V088; -.
DR STRING; 6210.W6V088; -.
DR EnsemblMetazoa; XM_024494987.1; XP_024350580.1; GeneID_36341453.
DR OMA; KHYRIAN; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:UniProt.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003972; K_chnl_volt-dep_Kv1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF254; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01496; SHAKERCHANEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..308
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 66..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..681
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 90664 MW; 9CFA944D8689C07C CRC64;
MGFEMIVAVL LRKHLGNVSV ARDEQSLSAD DEQYSVRAYS NLPGASGIGG TGLPSGGYHA
NATTSAGSHV TFGAPTTTTA SSSNLRPTES SSSASVGAPP ATTCDTRISA VGSTVAALTS
GQFGFSQRNP LLRSSSFSRN LSDSKESQSD GTMETNAQMR TKILTKASVM HSVDWDIEGA
QFSEVSDELQ PKEQYDMSFC ERRQADEERV VLNVSGLKFE TQLKTLNRFP NTLLGNPRKR
NRYYDPLRNE YFFDRNRPSF DAILYYYQSG GRLRRPVNVP IDVFTEEISF YELDDEAVEK
YRIDEGFLKE GVKLLPENEF QRKIWLLFEY PESSLAARCI AICSIFVIIL SIVIFCIETL
PHFKHYRIAN RTSKLSSISN AAEDGNNYVS TGATVFDSGS SFLRTVRDTS ASTQTQWNDL
FYNVIIVEDD IPHLAEPFFI IETVCIIWFT FELMIRFASC PQKVAFFKNI MNFIDIVAII
PYFITLGTVI ADDSKRQNQA MSLAILRIIR LVRVFRIFKL SRHSKGLQIL GQTLKASVRE
LGLLVFFLLI SVILFSSAVY FAEVDAEKTF FRSIPDAFWW AVVTMTTVGY GDMRPVTVGG
KLVGSLCAIA GVLTIALPVP VIVSNFNYFY HRETETEEKP SFTTVSSCPL CKTPSLCSSN
SGDSLLSPKK KHSRDGSGYR SSRSDGRGQP TVSREESQPT RVSQGNSAGI PLLSNADEMP
TSRLIAEPDR NTEERDKKVS RHRKKGTLMR PGLLNFITQP LQQAGIGSRE SLDQATEMKK
RRNFNPTSLP PSPQAVVVSN TVLLPPLKSH QENDH
//
