ID W6V1I6_ECHGR Unreviewed; 710 AA.
AC W6V1I6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Thioredoxin domain-containing protein 3 {ECO:0000313|EMBL:EUB59729.1};
GN ORFNames=EGR_05349 {ECO:0000313|EMBL:EUB59729.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59729.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB59729.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|ARBA:ARBA00008142,
CC ECO:0000256|RuleBase:RU004011}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB59729.1}.
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DR EMBL; APAU02000039; EUB59729.1; -; Genomic_DNA.
DR AlphaFoldDB; W6V1I6; -.
DR STRING; 6210.W6V1I6; -.
DR EnsemblMetazoa; XM_024494598.1; XP_024350925.1; GeneID_36341064.
DR OMA; MACKADG; -.
DR OrthoDB; 5481442at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR CDD; cd04416; NDPk_TX; 1.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 3.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR PANTHER; PTHR46161; NUCLEOSIDE DIPHOSPHATE KINASE; 1.
DR PANTHER; PTHR46161:SF3; NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED; 1.
DR Pfam; PF00334; NDK; 2.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00562; NDK; 1.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 345..483
FT /note="Nucleoside diphosphate kinase-like"
FT /evidence="ECO:0000259|SMART:SM00562"
FT REGION 178..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..520
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..564
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 80654 MW; 8B074C0201A3D25D CRC64;
MLKQEHAVLA GEIARVEIED PYLKVIEEEK AAEAKRKRTQ REVDEECCPV VLHPDLREET
AEAIIETFKD AKYEILQDAV IKLDIDMASE LLADEIDEPD YASRINKLMR DPLRVLIVAR
GSEGVFNEIA KFIGPKSSEG PLEDENFKRA IKMLYPEFTP RRVIVYVPDT EEIRPSVHPM
EEKKDSLMDD EISEGSSGVP EYQGPPRVIV LVKPPAYGSY RHAVITDLEA NGFKVLSTKD
YTFTEEEARE HYADLASLTL FEGLISVMTS GPSFIIMACK ADGPRALKDI LGPESYAQAL
KDSPDSLRGK YSSFPEIPKE DDLTWIDGTI AEPQAQNTVI RFFPVEETFA LLKPDSQPAW
DEILDDIKRA SFKIAAKKEV QLLPEDVRVI YEREVDKPYF DDLVRHMTSG PSLALVLKAQ
DAVKKWAKLI GPTDPDVAVD SYPPDLRATY GRNIRDNAVH GSSSVEEAKK SIRLIFSSGS
HDSDGSCFIE EEDEDDEYDY DDDDFCNEEQ REDENEEEYE ERMSRCEKRR RCHEKRRARS
TLEETEEEEE EEEENAEEEE ERQIYEKEEE KTEKEHEKVV EKSKGKKKGK SEGSHSKSGK
SKTVSVEETQ PPTTIEEVKE DTDMRATVED DGTTITSPPP QELQETTEAT EEANVEEANP
NNQTRPRWRV KKLLPSSVDT SWGVAHRLAH IGCYSSKAAP PGRLPRSLWP
//
