ID W6V3M2_ECHGR Unreviewed; 448 AA.
AC W6V3M2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=E3 ubiquitin-protein ligase MARCHF5 {ECO:0000256|ARBA:ARBA00040151};
DE AltName: Full=Membrane-associated RING finger protein 5 {ECO:0000256|ARBA:ARBA00043185};
DE AltName: Full=Membrane-associated RING-CH protein V {ECO:0000256|ARBA:ARBA00043044};
DE AltName: Full=RING-type E3 ubiquitin transferase MARCHF5 {ECO:0000256|ARBA:ARBA00043231};
GN ORFNames=EGR_04457 {ECO:0000313|EMBL:EUB60624.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB60624.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB60624.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB60624.1}.
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DR EMBL; APAU02000028; EUB60624.1; -; Genomic_DNA.
DR AlphaFoldDB; W6V3M2; -.
DR STRING; 6210.W6V3M2; -.
DR EnsemblMetazoa; XM_024493706.1; XP_024351820.1; GeneID_36340172.
DR OrthoDB; 2718337at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46283:SF2; AT07234P-RELATED; 1.
DR PANTHER; PTHR46283; E3 UBIQUITIN-PROTEIN LIGASE MARCH5; 1.
DR Pfam; PF12906; RINGv; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51292; ZF_RING_CH; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..151
FT /note="RING-CH-type"
FT /evidence="ECO:0000259|PROSITE:PS51292"
SQ SEQUENCE 448 AA; 50612 MW; 9C584CB754119539 CRC64;
MVHVSRAMGD NKDYAKMQLK GWKQKEAGRI WQAMKHALRE EPRRQPYEKD NVLILKPKIN
LLKLQKSVTN SGGNCSIRSG RGSENERMCW ICYGLEREDE SSQCWIHPCR CCGSSKWVHQ
SCLQRWLDER QRLDPLSPLS CRMCGYNYVV EYPPADPLLT ILTVVDQAVD VSSTYVFTGA
VMGCLYWSAV TYGALTVMQV CGHEAGLTAM EKMDPVVLLL GLPAIPTCLV AIHMVDWQSW
LLRLWRSHAY KLAMIQYLLP KDICRSRLEE ARDSESGSTI PRILCTSLAL PSFAVFFGRI
LFGRFQSRLG QAIAGGLFYL GFTGLLHIYQ REMTFLRNCR RHIVEYDGEC FAGVCVVSAS
VGLVVSRRRR SMGVWCCESS RQCPQGLSMW GSWDMVRCVI QSSVSLKSQK DLSQMEVSLK
GVFLTTIDVT NNAWCPDISF VPGVPQPA
//
