ID W6V5E3_ECHGR Unreviewed; 3025 AA.
AC W6V5E3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Ubiquitin hydrolase FAF-X {ECO:0000313|EMBL:EUB61484.1};
GN ORFNames=EGR_03548 {ECO:0000313|EMBL:EUB61484.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB61484.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB61484.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB61484.1}.
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DR EMBL; APAU02000019; EUB61484.1; -; Genomic_DNA.
DR STRING; 6210.W6V5E3; -.
DR EnsemblMetazoa; XM_024492797.1; XP_024352680.1; GeneID_36339263.
DR OMA; EYMLRSV; -.
DR OrthoDB; 6206at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF827; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EUB61484.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 1984..2369
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1150..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2953..3001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2953..2982
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3025 AA; 338700 MW; 4A5904377E2BD8D8 CRC64;
MSFGYKMTDK TENENVVQPV EKPCSPAYPP TPTEPDDSEV IISEQDFTPD FPVAEMDTMH
TKIRKPSWVV PVLPNEELET VLLACIKLVE TNQYERCLYF NKFCDQDLNS AFEKIICDRA
GDLWSDQTHH FIFMNSLLAV QLCACMADKD FAPIMELESR LFNPESKFHK HSVSNRSSLE
AIRFGTGETE SVSRFAVIMS ALPELRRSVQ GKNGGESSDL KIFATASMAR PLPLLEDFIN
LFGRLGGFDA LLERFRNYGN GSPTLRLFFN YLKPFKACCY YLTDEVVKDY FLPMTDIVLT
FMKNLTEADV RQSVRSDQRS NHLADFAVIQ QFYQRIYGPN YNIEEFDELH LQLILKTMRT
DLFGGKMNAL NDLITIICDI NTRSGNASKP FAMVDRLVKW LKDNQVLSLL LRSNLHQPQY
VEKVTRVVQF LVEMHELSLE DLEEIWEAQA GKHEAIVKNV EDMLARLVHY FSPEQLDRLF
DCFKKAFQTT TKRQQERLIV LIRRLTMENL IGLESKTLEF FWDLATRPSL LPEISAAALE
AHSGILTDAM KTAGSVQQNL AWLSRFATIL QEDSDDYAVI RAARQIIEVH QFLRVYHGNL
IHQLTVNNDL ITVCINSLRN YMHKYSVKNS KVAHDTGIDS ISSQPPSTTS TLGRGDTATP
ASSTCTNTLE LPPLQAKMSD DGGVSSQSEK PSTNHFQPIP HVEQIRERLE LLHFLAKESG
ISLTLEQMNL LWRCLIVDTE VDQDACSCAD SDSSAGCSST HSSATVEGRN ICFSWFNPNT
NGLIHPFLTE FFQDNILNIK PEVLTPAGMD LFRCFFNCVN TKLKSSEETT LQSQSDLMGL
DYLWHIVLAS NDGAARIAIE MLRELYTNDR DPLNDPRKLR FDFLKKCYDF LSSSYAKIYG
LLLAHGIASP DGSACRLFNN PQQLLLITRD AEQDLSNIDR VIRVLRRFLI ECDRQFKTPR
VHLPLFQSWS GSSILLTVNF NAVKKGSAED LKLQKYGATE GRQYESSTMT IIAHANETLG
RLRSRLLICR LKEVLLPLNS PATNAGGDEG ALSCPAKILD EFCVDLCEAT GLSGNLCLST
FLLISSSDLR GNFNTSLDST SFNDDMKSLT SLSAFLYLPA TSTPFYPDGP YIPGSSNVFS
LPQGPRECGS FPSMGNCSSS SSNRALRAPR GSPSPTLTDD ENVQMPVRGG NVGGDYSVNA
GSASLPHSIS SETNQDDLMG SPSDDGDGAK SPPTEPVAGA NPSSTARGDC VTEASPPSAP
LNELRKECNL PDYVMSEDLN FVHLLLDIGN VAVFLGINEL RDRTFDVLFS LPMNLTYRNV
LCESLHSHKG IEKLTDLLKC SISELNLPCT PSKIHNNLEF PGVTHQLYLL QVLYATLNPS
VEIILCINDA KCFSRHFTLE SFSYTLAFLR NGGLGSLLSA CALGDTNAVT ADPLSQLILL
WICRILYLGL YCVMATLVLV FDGSTVCLAQ MKALWGVKSA SALSTGDCIL QKYAEAFSHF
AVNAGVTMAE IQSAWLNIPP RSCELLRDVI WLISSALPIA SISSAHSQRK ATIAHSHDSG
CISPRTDVFC HPTPPSVTCT FSTTCGLKSA PLQTFFQIGH LDSSDLSIEC LQLLPSEPHY
CPSPVTLPYI LNLNSGRTPG CLSTTALSTL SFLLSLSPDS SLVDFLLHKV PLSHDHEVLK
SWLDFLRHIL VLSPSSHLRQ SATCLLNIVV TCGLTVAISL QPSSELDAPA STTDVVGFVI
DFLVKALNES ESDQALYSAD CTEVLVGIMD FLQSESLTLD TAENLFVNEW AWLSKRITVP
SSDSDEGGCV DTPTHLSIPN LFRSHLRLCT CLIPFQNRKL FDESNKDFIG LGPVDALLEV
VIFPAAKRFN ELQRRLSLET WELAREITSA SAILEVSRVI STPPNGILNA AFDLLLKLAL
FVPRVLYPFL SDKICSLLYS FNTRVTEWEP LDPLPSSNRS PNNNSKRNCL SFNAESLCGS
PGFVGLKNAG ATCYMNAVLQ QLFAILPIRN AILSAPVSDT LQKAGVNIAS LHSPYAPPLS
PKGDLSASQL SHLCTLFSLQ DMFAFLAYTR RAFYDPSLFL RHFKLWGEKV NHSEQHDAQE
FLICLVDNLD EAMKICGMPK AIENVIGGTF EDQKICIDCP HRYQREESFL VISVEIQNRS
TLCESLEEYV KSDLLEGDNA YHCDHCDKKV AARKRMCIKR LPQILAIQLK RFSFDWERHV
AIKTNDRFSF PFELDMAPYT VEGLACCNQV PCVGESGGAC ESCPASPGAT EAEAPRQPTR
YTLRGVIVHS GEAAHGHYYS FILHHNRETG KSQWYKYDDT RVTEVIADSP GFEQTEWFGG
EYTSETPMRF SYRPYMRCYS AYMLFYERED FKEVNIVSNL CSSMQSVGLS DGTAGLVPCP
PHIASQIYAQ NVEHFNTSML MNPIFEQFVH RLATADCLRQ QSANAPEWMK TYEALARLLT
HFCFDSRFHT KENNWCLWFH PFFELLRVGP SVREIFTQRT CFSSPNQIHD FFFRCPYPGV
RYLYGALLIL VVFLELKSNP TKPVADQIMQ KLIAELPSCF ASTSSELFYH EPPLYGPVTL
SGSYWNPSTD DSRHEIQQSA CGGQLLALLL DYARLGPLLT EHLARLGLHT KLMHYLIGSL
PNTSILCRPL TLVTSHPATA DQMERYMSDL DKSIGVDFAH KVAFSSRLLV TYELIRNQTK
DSVGTSISFL PPDKSPAFVS TASFKPRLFY LSPSATVHLS PVNHYMDLLV CLFSHSELEE
SSLNLSNMLG SIDFDRFIQV ILTCCLNQGS VVTIIQLIKI VTQNDTYRSR VVIDELMRII
FPSHLSPLMK LAPELAIPVF MEALSVSDSL QELRLSYAFQ SRRFYDVLTL IKRSNPKIWN
DPGMNMLRAL SSMVINFEAF REYFESQRRI GLHFHRIIND VIEVEYHQAP GSGEYYAILN
QAKGVLPVPN SYDEEVEEEI EAEEGNEEEE EREEEEDEGD YENNGLNDTR VMPDNGETEC
EQIRMAHFKT DYLEHQEESI KDADM
//
