ID W6VAS5_ECHGR Unreviewed; 2316 AA.
AC W6VAS5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Triple functional domain protein {ECO:0000313|EMBL:EUB63884.1};
GN ORFNames=EGR_01012 {ECO:0000313|EMBL:EUB63884.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB63884.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB63884.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB63884.1}.
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DR EMBL; APAU02000004; EUB63884.1; -; Genomic_DNA.
DR STRING; 6210.W6VAS5; -.
DR EnsemblMetazoa; XM_024490261.1; XP_024355080.1; GeneID_36336727.
DR OMA; FYDHDEW; -.
DR OrthoDB; 2906033at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF201; LD43457P; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 1492..1675
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1695..1804
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 27..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1430..1479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1864..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1933..1984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1443..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2316 AA; 255413 MW; 882CF2AFBFE1A47C CRC64;
MDHSSKHIDS DVLDFYRPSH IGENRLSSSG HNCHLHDQHS SGNQHRSQGV PQLPLHVKVS
SGLRVPLTAA VHTAYGVHPQ LPRVYQQGRP QSASQHHLGR QVHPEIFRHS PQSCQSNQSG
CTASISSGTS GYASLNSNCK GGHKPSGARL RAAELIPLLR GKYAMLPGGR TRNGGPILCF
PANSHADFLP LEELYFLVLY LTYLPEENVK KLGFAVIIDM RSGTTWHSVK PVLKVIEECI
GGNVAMAYII KPDKYLEKQK VQMSIGKFSF NIQLVSVEQL FLEVDASQLT ADLEGTLPYN
HEEWIQIRCC LEEFFMFAHD MSDKFSQLYC FLDQKQNPES VEESKRALED HRSVRLKVMQ
APVPALEAES DRLTAWLRYG ISAAASASAS GGAATAVSTA AAGLPSSVGN AASSSGASYV
PSSWVSMNPD FQQVPYEISY NWYLSPLNYT WIEILLKLRF GKLLSVCLLP FADFPYPLQL
IPQVRQTVTQ LYEFRAHLQQ KWETGRTRLE QIYQFRLFED DASRMTAWLE QQSVLLLTEH
ADIGETASQA VELHNQHRQF LQKCSGVREQ VSRLTGIARM LADTGHFAGQ QMLKQANELE
HERKSFTTAL EERSRVLQLS TSFHTRAEAF LNNCTTWETS VRHVSGTNVN DLNQALRLIQ
ERWQDIQQSY EEACRDGRAM VDLLSAPVTG GSHTSLTAAI DYSQGRKHCA DLVHELWAWY
KRLERTFTDR KSRLTSRLAL LMFKEDVGQV LTWLSDHGEP FLARQTAIGK SSQRAEQLYN
AHMQFEQVAA NTLTNADKLI SAVEELASQA ENPREVRQEA AKLQQRITSF TNAVDSRREM
LDLACGFYGH TKEVLNWLHN ASEAYNPGEH FPPTIEGMDD ELTAFRQHRD SLEVAVKRVV
SEGKVLISRL QDSEEAAHLR SILTQVTNER DAVWELLGDR QMRLELCMQL RLFEADVHNS
MEGLRRDVPA ITAVVNATSA VPSTSPTAPT AATESNVASA APSTSGVSSI STAATDLYWI
SDPRKAPSIS ALEEVNVSCT AILPKVEEVL DKGGELIRIF ESVAVNFPAG GPGSSDSGVG
DSSETAVERV HRLISELGES VATVDEINER VSNELDWRRL QSQSRQVLKW IGQCEVILYQ
TAVIPTSLAE AEAMQTDHDK FQPVLNDAHP EAVQCAARAS YLLQSVAADH PRRADFQAVA
ENVAERWQKL VYAAEEKHKL LIAATNWYKT SEQVISVLRS LEKDYRREED WCRSDKALNS
GNVESYLNDL LSKHGEQKEA FLKACILARR TSELFMKYLH RQPPTTACRT KVEERIRSDM
ADLMAKEQAV LEAWAAQRRR FEECVKFVTV EAEMLDLARR ILQFVGGPVK SAEDPKVALP
LLPRQSSLFA TVKRACQSLK ALLEAGVGAH HSDSLLKTYH RLNACVAPVE TPRPPESDSA
SAAAAKMRST GTGSNRTSVS STGSSGVASS DTTPSITATV GLTEEQRKLI NRRQNILREL
VTTERAYVLA LRTCLETFHA GTMNPPVDIP VPSYIAGKES IVYGNLEEIY HFHEKFFEPE
ICKYASGGDF LPEDVGHCFV SFGDRLAGLY VEYCVNKEDS MQILVADTEN FFGRLQLRYQ
LSEPLQSFLI KPVQRITKYQ LLLREIRECC DKSSAGELSE GLDVMMAVPK KANEAIHLRM
LQGLPEDLPI SCLGDVVLQD QFTVWEPKQL IKKSRERRVF LFDICLVLAK ECPVNPGESK
MKYQFKSRFL LADLNITEHI EGDQCKFALW AGRVPPVNDY RLVLKAPSLE VKQTWVRAIR
EAMRERMFSM QSLHQDSSAA SGKLGADSVS TLDAYYIREN YQAQGPNEIS VAAHQIVQLV
QRTTHPSVES VSTPPPTPIG SASAEREADG TSEPSWALVR FVVTGSASSP NAPVDEGFIP
VRLIGAPVYP RAASVTAGGS SGGRRSMRRW LPSAGSGTKE RRQVLPGTPA SGKRGSKADM
APPIPLVNRS LAAPTQHPAT SATSVATQDN TALLDNVSEE SVELELPPPM VELQALPTAS
AVTSAVESET DVASEVKRAE EDGAAQTANS EINLSRMVEI SGEADGGGGT GPYLPPVLTG
VPSDLQQNAL GALRIHGALR VATQLVGALE ASLADLTIGG SSATDASSRP EGTACTAAQD
EELLKAIAED STTLCFVNRH LLLFDQGLVI ADAAVEAISR TDGVTRQMRC QFRHFLSFSQ
IALLEDISVA GSRPTEEQVL WFCVSERPRR STTSAVCGGM GGAEGSLQSH LCHVLAPHSP
EVRIRWLSEL NAALEQGKRC SAIVTVSGDE GLIMDP
//
