ID   W6VCC9_ECHGR            Unreviewed;       659 AA.
AC   W6VCC9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Protein CASP {ECO:0000256|ARBA:ARBA00018691};
GN   ORFNames=EGR_00469 {ECO:0000313|EMBL:EUB64519.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB64519.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB64519.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC       pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC   -!- SIMILARITY: Belongs to the CASP family.
CC       {ECO:0000256|ARBA:ARBA00006415}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB64519.1}.
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DR   EMBL; APAU02000002; EUB64519.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6VCC9; -.
DR   STRING; 6210.W6VCC9; -.
DR   EnsemblMetazoa; XM_024489718.1; XP_024355715.1; GeneID_36336184.
DR   OMA; FAGYCFA; -.
DR   OrthoDB; 74668at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR012955; CASP_C.
DR   PANTHER; PTHR14043; CCAAT DISPLACEMENT PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14043:SF2; HOMEOBOX PROTEIN CUT; 1.
DR   Pfam; PF08172; CASP_C; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        618..636
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          421..640
FT                   /note="CASP C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08172"
FT   REGION          144..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          184..352
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          397..445
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          497..531
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        169..183
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   659 AA;  75164 MW;  5E91374FAF01F942 CRC64;
     MLSIVNSTKS AWNEFQFPKF QVEIGEIAST IASVQERDRF SRKKLVDALL QFRNSVPEEV
     RKAAASVLKS FQTEVDRLTI RSQKAEDAFI QVYQCLAEMP DPSLALAEVE SISKEAQCAS
     DLKIENARLR ETIEGLKRGL YVGKSEASPS DAEPPLRKDE EEEGIVEAED VEEKKRKGRD
     AQAEERWKER ERKLQALLDE ANNRSSEAEA QVKYLFDALK DAESHAFDLE TDLKELKAAN
     SQQVQTLLDE LEKANDTIVA LEEARAAEAD AEKIKEGTHP SNCKETTELQ NRIEELESEL
     EAKTAEVDKL KSQLQEMETQ FKAEIANLHE RLESTNSALV SANESLASAQ AELRGKYDYD
     EIKRELEVLR SIEFQHQDGD PLAMMDEPLE FRLLRKTDQL QNRIASISSE RDRIESKLMA
     LQKTNADMAE REAQQKALIA RLEEDLNRAS TWHHQKRANT SSYVGNGDEV VESASPLTDL
     LIYEQEEKSI AAESSILDIV QNQRDRLREQ NRELEENLLA MRQQLITSQT EVESLRQDNV
     KLYEKIRFVQ AYSPSTSSSL DRDDAVLARY SSAYEERLNP FRQFGQQERQ RRYQALLPHE
     KIMHNLGRII ISNRGARLAT FAYVLVMHLL VFLVLYKMVT ATDPVCPSVH GSKDGRPDQ
//