ID W6Z6E3_COCMI Unreviewed; 797 AA.
AC W6Z6E3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN ORFNames=COCMIDRAFT_95233 {ECO:0000313|EMBL:EUC45565.1};
OS Bipolaris oryzae ATCC 44560.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=930090 {ECO:0000313|EMBL:EUC45565.1};
RN [1] {ECO:0000313|EMBL:EUC45565.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 44560 {ECO:0000313|EMBL:EUC45565.1};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
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DR EMBL; KI963982; EUC45565.1; -; Genomic_DNA.
DR RefSeq; XP_007687955.1; XM_007689765.1.
DR AlphaFoldDB; W6Z6E3; -.
DR STRING; 930090.W6Z6E3; -.
DR GeneID; 19128611; -.
DR KEGG; bor:COCMIDRAFT_95233; -.
DR eggNOG; KOG1514; Eukaryota.
DR HOGENOM; CLU_012774_1_1_1; -.
DR OrthoDB; 118994at2759; -.
DR Proteomes; UP000054032; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF01426; BAH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SUPFAM; SSF82061; BAH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058}.
FT DOMAIN 79..203
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 248..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 88189 MW; DBFC6E7D7452A727 CRC64;
MAPIKRSKVD KARQYLSGGA VFREDSDDEL GYEDHPWEWI YQDNAADDTQ PNQNATPRKR
KAAPELLGRH IVGARMGNFK CKVGDAVLLK AEGNQAWVGI ICDFYEDVDE DEKMAKFLWF
FSEKEIRNQN KKRTDFLPNE LYISAAFDDN PLASINGTAK IYSLERYQEL YPTGVKKSSK
DYGKVFVCRR GCSTRTTTYT PEFRWEDIYN SAEDIQALVD LVESQTKATR KGPGRPKKQL
QKDLDEFVAP DAAHEGQPET PRKRRKLYDA TTPTSTKKSP AARKFLTPSH KRIVVKKQLE
FTPLGTRVLD PSTLNSPFQI ARNQLHVSSV PAALPCREEE FSTVYSHLEA AITEGSGSCI
YISGTPGTGK TATVREVVAQ LQASVQAEEL DDFIFVEING MKVTDPHQSY SLLWQALRGD
RVSPSHALEL LEREFSTPSP RRVPCVVLMD ELDQLVTKNQ SVMYNFFNWP GLRHSRLIVL
AVANTMDLPE RTLSNKISSR LGLTRITFPG YTYDQLMQII QSRLQGVPGN IVHPDAVQFA
ARKVAAVSGD ARRALDICRR AVEIAETETE IKSQDRDNEV QPATPSRSGR NNKANLVPTS
QSITTTGELV GQRADQAGHL AQRRGVVTMV TIKQAINEAT SSPLQQALRA LPLASKVFLA
ALLARIRRSG IGEVVLGDVV DEVKRLGLMS QLRPVHEYIL APEKDDRIDG GIGAVVQPPT
PSKHRDAPNM GSKQSDLKVA RALGLAHAAT ELAEAGIIGV EARHGERVGR VRLGVGEDEV
RLALGDDESV HGLGLGA
//
