ID W6ZEN6_COCMI Unreviewed; 1113 AA.
AC W6ZEN6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Sodium, calcium exchanger protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCMIDRAFT_1009 {ECO:0000313|EMBL:EUC50287.1};
OS Bipolaris oryzae ATCC 44560.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=930090 {ECO:0000313|EMBL:EUC50287.1};
RN [1] {ECO:0000313|EMBL:EUC50287.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 44560 {ECO:0000313|EMBL:EUC50287.1};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI963924; EUC50287.1; -; Genomic_DNA.
DR RefSeq; XP_007683117.1; XM_007684927.1.
DR AlphaFoldDB; W6ZEN6; -.
DR STRING; 930090.W6ZEN6; -.
DR GeneID; 19117764; -.
DR KEGG; bor:COCMIDRAFT_1009; -.
DR eggNOG; KOG1397; Eukaryota.
DR HOGENOM; CLU_001583_0_0_1; -.
DR OrthoDB; 8346at2759; -.
DR Proteomes; UP000054032; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR005185; YccF.
DR PANTHER; PTHR31503:SF10; CATION_H+ EXCHANGER PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF03733; YccF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 253..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 985..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1024..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1069
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 256..309
FT /note="Inner membrane component"
FT /evidence="ECO:0000259|Pfam:PF03733"
FT DOMAIN 529..716
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 915..1068
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 122728 MW; B750742DBF3104F4 CRC64;
MEDRTPNSGE AKPSPETSHR SSTQGTTTAS DTPAQTAMAG ESARRRSQAA MQPSGYGTIS
TGKDSKDRRP QNPPVSEGSS KPKKPSMTRR TTSSKWPQKG QEFSVDDAEE EVELDQAQQD
QQKKQRQTLR RKSSTVRRRT AAQPATLTTI DSTEDDEAEQ DSAGLTTGTD ADATPVSSSE
ETVQAEDESG GADDDELSDA ESFTLRDRQD AINVTHPFGI RIWKPALYKK GRSVQRNAEA
DIHSSPGLYV SRWLLLFNLV WTLVFGWWLA VVASAGGLLC ALLGFNQSCK EYSRLLFHLA
SYLFYPFGKY VKLMQDEAYI DEDEGEGRSI SEYEQWQSGD IEEGRLFFGP INGGESSLVG
RRRNSVDSAG SETMSLLGRH GRGNVNHTDT ATTKRRLFGR GKWTLGRVIF FLFFYGILMP
SLFFVSILCW FLVFTIPMGK TTMLLLDHLR RHPLALSFHS DNGNVRRPGE SSSILLCTYR
AVGIKYWKYT IDGTNIFLIN LLGLVAFTIF DYFVLAEAME LKFWLTDQFL LFTLALLSII
PLAYFIGQAV ASISAQSSMG VGATINAFFS TVVEVFLYCV ALNQGKAQLV EGSIIGSIFA
GILFLPGLSM CFGALKRKTQ RFNVRSAGVT STMLLFAVIG AFGPTLFYQI YGSHELNCHQ
CIKPHSSAPL ERDCRRCYYS QTPALHDRFY NEAVKPYTWF SAALLFFSYI IGLLFTLRTH
AATIWTEPDA QEKKFLEMSA SSLSQSGHGD FPHSSFMRQS TGHSVNRAHV RDSQLYKRMV
SQTLQEVGIG PEQSTSSDRR PGSKADSNTP HLVPPKDGQT NVHHSFHVEG LTDDAAESLA
RQITEIAATT TALATRDVTK TPRKVAQLAH TTSKGHSDRP AHTRANTEAA HDEGETAPGH
TSGGHDAPNW SRQKSAAILL TATVAYAIIA EILVNTVDGV LEGSDIDEKF LGITLFALVP
NTTEFLNAIS FAMNGNIALS MEIGSAYALQ VCLLQIPALV FYSAMHSGYI PAHEVANQSF
TLIFPQWDMI TVILCVFLLS YMYGEGKSNY FKGSILILSY LVVIAGFYLS GFNDFERMGV
DPKDTLALGG LVEQQMQSMT FKTPGRGRSG VAY
//
