ID W6ZHK9_COCMI Unreviewed; 858 AA.
AC W6ZHK9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=COCMIDRAFT_131 {ECO:0000313|EMBL:EUC51332.1};
OS Bipolaris oryzae ATCC 44560.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=930090 {ECO:0000313|EMBL:EUC51332.1};
RN [1] {ECO:0000313|EMBL:EUC51332.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 44560 {ECO:0000313|EMBL:EUC51332.1};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KI963918; EUC51332.1; -; Genomic_DNA.
DR RefSeq; XP_007682065.1; XM_007683875.1.
DR AlphaFoldDB; W6ZHK9; -.
DR STRING; 930090.W6ZHK9; -.
DR GeneID; 19119837; -.
DR KEGG; bor:COCMIDRAFT_131; -.
DR eggNOG; KOG0477; Eukaryota.
DR HOGENOM; CLU_000995_0_1_1; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000054032; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 479..685
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 95604 MW; 6719164B1BFB75BE CRC64;
MSSANRGAGP ASRSNKRARD DEDLPSSAVH PPSSPMASSP PMLPNEDDAD MLDDDDIIRD
VDDLEEDAEE AEGIDLFADD FENDYAAREN DAYEGQGIDD EGEYEELSLA ERRKLDASLN
ARDREARRRM PAAFLPDDDE QDGLAGLMGR RRVRRHRYDE EDDMDMADDI MNEELTLEAL
TDVKANTLTD WVAQPQVART IAREFKSFLT EYTDEHGHSV YGARIRTLGE VNAESLEVSF
DHLAEQKATL AYWLANTPTE MLKIFDQVAM EVTLLHYPDY ERIHSEIHVR ITDVPVQYTL
RQLRQSHLNS LVRVSGVVTR RSGVFPQLKY VKFDCTKCGV TLGPFHQDSN VEVKISFCQN
CQSRGPFTVN SERTVYRNYQ KLTLQESPGT VPAGRLPRHR EVILLWDLID SAKPGEEIEV
TGIYRNNYDA ALNNKNGFPV FATILEANYI VKSHDQLAGF RLTEDDEKEI RRLSKDPRIV
DKIIGSIAPS IYGHTDIKTA VALSLFGGVS KEAPGRHSIR GDINVLLLGD PGTAKSQILK
YVEKTAHRAV FATGQGASAV GLTASVRRDP MTSEWTLEGG ALVLADKGTC LIDEFDKMND
QDRTSIHEAM EQQTISISKA GIVTTLQARC SIVAAANPIG GRYNSTIPFS QNVELTEPIL
SRFDILCVVR DTVDPAEDER LAKFVVNSHG RAHPLVNSTY GYSDKAKASQ NGDDQMEVDG
DAPVKEGEIP QELLRKYILY ARERCRPKLY QIEQDKIARL FADMRRESMA TGAYPITVRH
LEAILRIAES FCKMRLSDYC SSVDIDRAIA VAVDSFVGSQ KVSAKKALAR AFAKYTLNRP
GAVSAPTRGG RQTQRAAA
//
