ID W6ZIU5_COCMI Unreviewed; 1151 AA.
AC W6ZIU5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCMIDRAFT_22484 {ECO:0000313|EMBL:EUC49923.1};
OS Bipolaris oryzae ATCC 44560.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=930090 {ECO:0000313|EMBL:EUC49923.1};
RN [1] {ECO:0000313|EMBL:EUC49923.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 44560 {ECO:0000313|EMBL:EUC49923.1};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
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DR EMBL; KI963927; EUC49923.1; -; Genomic_DNA.
DR RefSeq; XP_007683511.1; XM_007685321.1.
DR AlphaFoldDB; W6ZIU5; -.
DR STRING; 930090.W6ZIU5; -.
DR GeneID; 19120258; -.
DR KEGG; bor:COCMIDRAFT_22484; -.
DR eggNOG; KOG3417; Eukaryota.
DR eggNOG; KOG3655; Eukaryota.
DR HOGENOM; CLU_002632_0_0_1; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000054032; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 728..858
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 897..1134
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 71..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 128201 MW; 843AF364CCB013FB CRC64;
MNGFSGTTDA GGMYVKALYD YQADDRTSLS FRTGDVIQVI TQLESGWWDG VIHGVRGWFP
SNYCAVVQRP SEDIEEDRDG ADADDDTRSA SGAEGDYSDD GSLSGGNDTI LPIERNTAPA
NNKEEEAAFW IPQATPDGRL FYFNTLTGVS TMELPLESPA TNESGPRNRT DVFIPEMSRP
PAEILASGSG YNMEDTDDET SASDFEGPGT KGSYTSRHRQ RLSGGLSSAT SMESMNGGYH
GRGAYDQSSM SFAASAAMPP AGTTATSFAN SPGLGGPNGT LPQSRKFYDD VSPVPLTWNR
MVEDMRRAIE RYKQAINNSD RSEFVKRAED ISDHLRLLLA AGSGTTDNHS GNPSIISTNK
ALYPHFRETM SRFSKLVLSS HIAASDFPPP DSYSKCLKEA EGVMNGVFGF VEVARQQRGE
EIPRLVPGFV VGSNIGGSWQ NNGADSRDVN TSMYSDPEDH EPSSVEPTLK LDSRVLERLH
DVKRLIVSSI RRLDEHLVVR DTVISHQKHQ EIGDHVCNAA SKVLEACRPW ISTIEQINLA
SLDLDSQGSQ LSEFSIQKQK TYDIVSELVI ACQGVAAPLG DEWAELRGDS LEDRINAVRA
VARELESTCA QEYALLQNLS ENIPLDDIIS RSDPRRNTDS ELPSHARIPS GPERPLLGNM
PKADTYSPGS SLGNDDTKVE PIRSANSNKK LKDFFGEVPV IPQQAVEETP EFLKLDHEGE
ISYDHKTTPP QLKGGTLAGL VEQLTRHDRL DPAFNNTFLL TYRSFTTASE LFEMLVKRWS
IQPPHGLAKE DYQHWVDKKQ KPIRFRVVNI LKSWFDNYWM EGNDEEARIL IQRVYNFAKD
HVATTSTPGA APLMTSVEQR SRGPDMPTKR LVLTLSAQTP QPILPKHMKK LKFLDIDATE
FARQLTIIES KLYGKIRPTE CLNKTWQKKL APGEPDPASN VKALILHSNQ LTNWVAQMIL
TQQDVKRRVI VIKHFVNVAD KCRQLNNFST LTSIISALGT APIHRLNRTW SAVNQRSMAT
LESMRKLMGS TKNFAEYRDT LHRANPPCIP FFGVYLTDLT FIEDGIPSLI KRTNLINFAK
RAKTAEVIRD IQQYQNVPYP LQPVPELQEY ILSNMQSAGD VHEMYEMSLS VEPREREDEK
IARLLSESGF L
//
