ID W7A3L2_9APIC Unreviewed; 2879 AA.
AC W7A3L2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Chromodomain-helicase-DNA-binding protein 1 {ECO:0000313|EMBL:EUD66245.1};
GN ORFNames=C922_03440 {ECO:0000313|EMBL:EUD66245.1};
OS Plasmodium inui San Antonio 1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=1237626 {ECO:0000313|EMBL:EUD66245.1, ECO:0000313|Proteomes:UP000030640};
RN [1] {ECO:0000313|EMBL:EUD66245.1, ECO:0000313|Proteomes:UP000030640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=San Antonio 1 {ECO:0000313|EMBL:EUD66245.1,
RC ECO:0000313|Proteomes:UP000030640};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium inui San Antonio 1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI965473; EUD66245.1; -; Genomic_DNA.
DR RefSeq; XP_008817254.1; XM_008819032.1.
DR EnsemblProtists; EUD66245; EUD66245; C922_03440.
DR GeneID; 20038714; -.
DR VEuPathDB; PlasmoDB:C922_03440; -.
DR OrthoDB; 232054at2759; -.
DR Proteomes; UP000030640; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000313|EMBL:EUD66245.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EUD66245.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1205..1260
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 1310..1486
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1619..1775
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 112..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2093..2208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2341..2386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2500..2586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2625..2667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2685..2796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2808..2863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..880
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..924
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2108..2135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2151..2185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2342..2378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2551..2586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2625..2646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2647..2666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2685..2716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2742..2758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2779..2794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2818..2853
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2879 AA; 315546 MW; 5C0ECED0AC37806F CRC64;
MSGNNPGGSG GSSANMHDAI HYGEMIEADK AGGIKGTSAS NSYMNQVSSN KNLLCTPSHP
SYLNSGNSVN MGKGNHFNAM PPSGGDATIS ITSSLLSSNE QNVQLRQQMG MNKNCGGASA
PSGTSSSGAS ASVGATGLHE SYQKPILSTY NMNSMQVQSS MGGHHMISAS QAGGSGTNQM
GGRYSSMNYP MQEMNPNVHM NSGKGAHTTS EMKHNSKDPN FLGTNNMKPN PFVNNMYYQR
NDVMLRNSSN SYNMHGNFYG YMNNGFYDGP SAAPSNCFKP TANMMNRGNG ASNSSASSSV
AGASSTGANY ADSLSLANHG EGGSLSGKGS VNLIDKSASL KSIQGSNTSS GGNAGSGVNA
VGGSNSSSAA NLSGGNNNPC ATSVDSTGMP NNVMMNMVNN NVMMNSMMMG SGAAGSGGAK
NAIGAGGLPG MNMGGMNMGS MSMGGMSMGG LGGMHGMATH RSNAAMEKAN SLSDVNSMRY
HHPMGGAGGN VYSKMGFNNL SDYPYDNYGA NHMSAKSECG PISKERKGSH GGKNASKQGK
GSKNLKEELL LEKDGMMNSG SLVSEGKSKS TRKGKGTVGA GAGGVATASM EQFNGSGMMS
SDQHSAGMYK KYSKNAENQL DVKDKKMGSG NNSGNVVAGG GETGMNSGAS HPYSMFPNYN
IKYPINVDMF GSMGINPYGM PTKGGSTYPN MNLMNGVSGS SGANEMTSSG GNSSTSAGSS
YGGMNKLGSM NSYNMMSGYG DNRYSNLKSM DPMKSYNDGM VMGGGGATAT AHHGGSNLSS
MMSMGSMGNV GNVSNYNNLS NFMHNRNYPN DVNMRMLSGR GVMGVNNPTN MCNSQTSMMM
MDGGAAGGAG VAMHANPSSG DPRFQNDDGD EEEYEYEDED MHGEAALYRG SKYMRKNTHG
RPRNKSRKSE TQKKDKRKKK KKKHGNNSLD TEEDEDNDLY VNTYVRKSHT KRSSKKSQLY
DPLEDRYNER AKRNEKNDIF VSPYIGAVEG RINLRERRKV KNYAQMDNYF ETDEEDKKVD
EEKMLLRQEK QIMGGIDRVL HHRRILDYEN VNNIRNNPFL YINKGSKGGV AVGDAAGGDG
AVADGATADG TSADGAPDDG TAADGADGKG AGLNEDPTVD DFYEEEDIED VSQVEFLIKW
LGKSHIHNFF CTYDYLKHFN GLKKVDNYIK KIKQSFQKRK YMTADEIEQE KIYSEIKKQI
EMDAIHAERI VTHRVCEITG DQLFLVKWMS CAYDQCTEET RETLIDHGFT KLIEEYFDRE
SKIYGAKAIS SAWNRGPLTA TKFDPYNETP FYLNGKKLRA YQLTGLNWMV SRMKRSLSVL
LADEMGLGKT VQTISVVGHM LYKEKLIGPY LIIVPQSTVD NWLNEFKSWL PQANVVCYHG
NAVSRELIRT HELKKVYVPN KGYRYKFDVC ITTPSILNSI SDVELLKRMP WQLMVVDEAH
QLKNRQSKRF IELKQFMAES KLLLSGTPLH NNLEELWTLL HFLNPQQYTH YENFQKKYNE
IENTSLIGEA KQKQLMQLQH ELHEVILRRV KKDVEKSLPN KVERILRVEL SPIQIEFYKN
ILTKNYEQLA KASGGAKNSL QNICMELKKV CNHPFLCCEP VDKDEYKERL VYSSGKICLL
EKLLIRLKER GNRVLIFSQM VKMLNILSEY LTLRGFKHQR LDGTMSKEMR KKAMNHFNSK
NSDDFVFLLS TKAGGLGINL TSADTVIIYD SDWNPQNDLQ AGARAHRIGQ TKTVQIYRLV
TKDSIEQTIL ERAKVKMVLD TLVVQGLNKK QNDNVNVLGG EGGNTSNGFT REELSKILKF
GAQKLWEKNS SKYSPQKMDE EDKTAIKGVD VDLDKILEEA EAHENADKAN KDLNSELNSL
HNSNNFFSGG NNLFGNGTGG IASEAGAGGG GIADDLLSSY NNITEFKYEP PANLKTNIYN
DSTKADELEE EEQNDKDFWD RTIPLEERLK LKRMKEEELL VHGPRKTRTR DNHNRNNSYV
ESSAVNTQMM NDEDDDSEEY TIKYHDKNKH LKKKRKRRTS THITEKDKFR LYRSLLKFGN
PYLRLDDIQV DSKLTKVNKN VILTELNLIV DTCKEIVEKV AKESSLKVNE EGGLVAAEAA
DEEEDEEEGG RTVKRVKDDE ADIKLLKEEE NNHTTTTTDS NHLTVASCDD SNGKKLDEGA
NDEGLVADRA ADGAKSYEEK RRQLGTKGRK SLKGGSSEGV ADGAEAAEGE AAEGEAVAGG
AVAGGGLFSG FLNLVKGQGG EEKVATVKGE MKKETKEANG AKEAKQAKEP DELNGKENDN
NSNEDSDGNN KTKGNERGRK IDAYTFYIGT NRANALDLCQ RLQLFKSLHE FVKEQNGGNE
YSFRLPLRSS SSSASTNVSS GVVEEGKKSQ QGQQLQEKTE LDGEVKGEMK AEVKAEGDVK
KEPVSDPLPE VSGDYLKLKL PDYIFNHLRD LATKDVKAWS NEDDENLIKG VYVYGFGSIN
EICSDVNLNL GHIKNVKCDK VKMRCVRILK MIEEFNSNVK DETTSKKRRR VRNRNRNKNN
DVVEAHGKGV GSSGGTTSHR KMKQEQEETG AIDAGTATTG GTNSQVKGSS GSNPRQSYYS
RRSSERVKSI YMNDDREDGV VTKKRAVCLP GGFLKRGEKV EKVEKAEQIN GGESTLHSER
RKGSTRSSGS AAKGERNANH SHNNSGGVGI VGGLRSLGNI GSFGSLGSNT INSRRSNNHP
GGGEASECPS SNENKSFGSK EDGEQAVKGI MGAPGATESG IATRRSHRSS SNTAKKYNMA
NDEGEIMTRR KSSRVRRGKN EASPLSTGKN NAVTANEDEY FDRYAEMDIN PEGGEGIGTQ
EGEDKQMVEG EMEEQMEGHM DDQVDSEEER KREKKHLKKK KKKKNYQMMK CCIKFKAAI
//
