ID W7A7U5_9APIC Unreviewed; 465 AA.
AC W7A7U5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN ORFNames=C922_02074 {ECO:0000313|EMBL:EUD67368.1};
OS Plasmodium inui San Antonio 1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=1237626 {ECO:0000313|EMBL:EUD67368.1, ECO:0000313|Proteomes:UP000030640};
RN [1] {ECO:0000313|EMBL:EUD67368.1, ECO:0000313|Proteomes:UP000030640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=San Antonio 1 {ECO:0000313|EMBL:EUD67368.1,
RC ECO:0000313|Proteomes:UP000030640};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium inui San Antonio 1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
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DR EMBL; KI965466; EUD67368.1; -; Genomic_DNA.
DR RefSeq; XP_008815895.1; XM_008817673.1.
DR AlphaFoldDB; W7A7U5; -.
DR EnsemblProtists; EUD67368; EUD67368; C922_02074.
DR GeneID; 20037348; -.
DR VEuPathDB; PlasmoDB:C922_02074; -.
DR OrthoDB; 47357at2759; -.
DR Proteomes; UP000030640; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR PANTHER; PTHR11080:SF2; LD05707P; 1.
DR PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642}.
FT DOMAIN 339..442
FT /note="Isochorismatase-like"
FT /evidence="ECO:0000259|Pfam:PF00857"
FT REGION 255..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 52151 MW; D2872B7862FEC598 CRC64;
MKCFVIVDAQ NDFLPGGSFN SRDDYLNALN KINAIRLRIH NCTEKDLIKL GNCKQMMQYQ
PDKLLKENIV QYHQCSNDID DEQKEGDILL FPWDDRMMTN CPTGLSSPNV CNGLQKQPAQ
GTVNGVEGMS NDPHRGFSLM GEDTAGSDAH VYNHHPNGSR PTPEANNVAL LNGTDERTNG
GIANFALNIL SVDYHPQYHI SFAETHRIVF EKINKNRGIK KSSVKMNGHS VPQVSTHAQV
NRLAGYEEEA EGVLGGDHGD EGVFGDDHGD DHADDGDGGI KRPLQADLLQ SAFLEKNKIS
NLTDVMKNLA NIKSTRYIYK NVNSVSDIKE YSKLNFLNES IDVWPVHCVR KTPGCKINSN
LIRHLNDIVI KKADTENHDS HTIFENREIN EKILKLLKGV SIKSVYISGF IFEYCVKETA
LSFFNLGFDT YIVEDATAYL FGREEDKDDL KKKGIKFVNS STMFD
//
