ID W7AAI0_9APIC Unreviewed; 560 AA.
AC W7AAI0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE RecName: Full=Pseudouridine synthase I TruA alpha/beta domain-containing protein {ECO:0000259|Pfam:PF01416};
GN ORFNames=C922_01303 {ECO:0000313|EMBL:EUD68283.1};
OS Plasmodium inui San Antonio 1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=1237626 {ECO:0000313|EMBL:EUD68283.1, ECO:0000313|Proteomes:UP000030640};
RN [1] {ECO:0000313|EMBL:EUD68283.1, ECO:0000313|Proteomes:UP000030640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=San Antonio 1 {ECO:0000313|EMBL:EUD68283.1,
RC ECO:0000313|Proteomes:UP000030640};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium inui San Antonio 1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI965463; EUD68283.1; -; Genomic_DNA.
DR RefSeq; XP_008815131.1; XM_008816909.1.
DR AlphaFoldDB; W7AAI0; -.
DR EnsemblProtists; EUD68283; EUD68283; C922_01303.
DR GeneID; 20036577; -.
DR VEuPathDB; PlasmoDB:C922_01303; -.
DR OrthoDB; 228626at2759; -.
DR Proteomes; UP000030640; Unassembled WGS sequence.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF0; TRNA PSEUDOURIDINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Signal {ECO:0000256|SAM:SignalP};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..560
FT /note="Pseudouridine synthase I TruA alpha/beta domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004887672"
FT DOMAIN 440..546
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 304..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 62836 MW; 396731E13A28F607 CRC64;
MNSILLLLYL SVLLKIESKG VSKKVLKVKV IHRGGPSFVA TKSFYVIRVK RNKMALHTVD
DETNPGDLNV LNEEPSTIGP NGASSVCNFP NEGTPPNRPK LTNILLIVDY DGTNYSGWTG
IENCSDVYLS ATRSYKNAAT EEEKRKKQTG ESNGTSKYDT VQNMILNCIL QIHGYGYQLN
RDEGDVKSNL KAFEFIGVSR TDKGVHAKEY ICQYVSYDRP PPCDGNLNKV KMALNGLLNK
DIKILAVLNA PFPDFNVRFN NLGKIYTYNF DIRIPSQPLE RNYAWQLSDD PRFAFLLRES
SKKKKKKKKE QGEEDKQEGS QYQNDCVTTN GLTSVDENLS FLFGDHAVRG GGAVASNKLT
CDEIIREEAI RKEAIRKEAI SDDLHCGGEE AQPSTQPSTQ PPTELPTQPD VSHSMRIINR
EGGSNLTIPC DMEKIKECSK LFLGHHSFEF FCGTLKGTEK QKKVNPFCNI HFLELHQLRS
NIYQFVIQGD RFLYHMIRII VGTLIQVGVG LLQYEDVRDA LHFSKPLKVK LCAPAQGLCL
TKILFPAAIE RDISAALLSR
//
