ID W7BXV0_9LIST Unreviewed; 576 AA.
AC W7BXV0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Adenine deaminase {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenase {ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenine aminase {ECO:0000256|HAMAP-Rule:MF_01518};
DE EC=3.5.4.2 {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
GN Name=ade {ECO:0000256|HAMAP-Rule:MF_01518};
GN ORFNames=PCORN_04248 {ECO:0000313|EMBL:EUJ31734.1};
OS Listeria cornellensis FSL F6-0969.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1265820 {ECO:0000313|EMBL:EUJ31734.1, ECO:0000313|Proteomes:UP000019254};
RN [1] {ECO:0000313|EMBL:EUJ31734.1, ECO:0000313|Proteomes:UP000019254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL F6-969 {ECO:0000313|Proteomes:UP000019254};
RX PubMed=24599893; DOI=10.1099/ijs.0.052720-0;
RA den Bakker H.C., Warchocki S., Wright E.M., Allred A.F., Ahlstrom C.,
RA Manuel C.S., Stasiewicz M.J., Burrell A., Roof S., Strawn L., Fortes E.D.,
RA Nightingale K.K., Kephart D., Wiedmann M.;
RT "Listeria floridensis sp. nov., Listeria aquatica sp. nov., Listeria
RT cornellensis sp. nov., Listeria riparia sp. nov. and Listeria grandensis
RT sp. nov., from agricultural and natural environments.";
RL Int. J. Syst. Evol. Microbiol. 64:1882-1889(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000479, ECO:0000256|HAMAP-
CC Rule:MF_01518};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01518};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenine deaminase family. {ECO:0000256|ARBA:ARBA00006773,
CC ECO:0000256|HAMAP-Rule:MF_01518}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUJ31734.1}.
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DR EMBL; AODE01000009; EUJ31734.1; -; Genomic_DNA.
DR RefSeq; WP_036077663.1; NZ_AODE01000009.1.
DR AlphaFoldDB; W7BXV0; -.
DR STRING; 1265820.PCORN_04248; -.
DR PATRIC; fig|1265820.5.peg.841; -.
DR OrthoDB; 9775607at2; -.
DR Proteomes; UP000019254; Unassembled WGS sequence.
DR GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR CDD; cd01295; AdeC; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR HAMAP; MF_01518; Adenine_deamin; 1.
DR InterPro; IPR006679; Adenine_deam.
DR InterPro; IPR026912; Adenine_deam_C.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01178; ade; 1.
DR PANTHER; PTHR11113:SF2; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR11113; N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE; 1.
DR Pfam; PF13382; Adenine_deam_C; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01518};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_01518}.
FT DOMAIN 68..351
FT /note="Amidohydrolase-related"
FT /evidence="ECO:0000259|Pfam:PF01979"
FT DOMAIN 402..569
FT /note="Adenine deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13382"
SQ SEQUENCE 576 AA; 62420 MW; D061361B610B8F26 CRC64;
MRKVKQLQER VAVSDLRAAA DVVIKNGRIV NVFSGEIMEG DVAIKSGYIV GIGDFDDAAE
IIDAMGQFIV PGFIDAHVHV ESAMVPPSEF ARVLLPNGVT TIVTDPHEIA NVAGAKGIEF
MLDDAKEAPL DMYVMLPSSV PATPFEHNGA TLLASDLCTL YQHEKVIGLA EVMDFPSVAK
GHKDMLQKMA DAEQHGGRID GHGAGLTRAD LNNYLAVGIR TDHESTTAVE AMDRLRAGMF
VMLREGTVGR DMIHTLPAVN LKNSHRFCFC TDDKLIDDLL EEGSINYNVR LAIANEIDPV
MAIQMATINA ATCHKLPHLG AVAAGYQADI LFLRDLETVT ITKVMKRGQV VVDDGLRVEA
RFQKADRAFE SPAIRHSLKR EDLKLAMGNT TANVIGMQPN SLFTEHLVET VTVQDGEFQT
SIEEDQLKMV VVERHKGTGC VGVGIVKGFG IRNGAIATTV AHDSHNIVAV GSTDAAIMAA
IEHITKIGGG IAVVKDEKVA SDLALPIAGL LSVQPYEEIQ HQLGRLNDAF RDVSAKQGFD
PFLTLSFLTL PVIPNLKLTD QGLFDFNRFG FIEVEV
//
