ID   W7DU21_9PROT            Unreviewed;       815 AA.
AC   W7DU21;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:EUK18530.1};
GN   ORFNames=COMX_02240 {ECO:0000313|EMBL:EUK18530.1};
OS   Commensalibacter papalotli (ex Servin-Garciduenas et al. 2014).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae.
OX   NCBI_TaxID=1208583 {ECO:0000313|EMBL:EUK18530.1, ECO:0000313|Proteomes:UP000019250};
RN   [1] {ECO:0000313|EMBL:EUK18530.1, ECO:0000313|Proteomes:UP000019250}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX-MONARCH01 {ECO:0000313|Proteomes:UP000019250};
RX   PubMed=24604647;
RA   Servin-Garciduenas L.E., Sanchez-Quinto A., Martinez-Romero E.;
RT   "Draft Genome Sequence of Commensalibacter papalotli MX01, a Symbiont
RT   Identified from the Guts of Overwintering Monarch Butterflies.";
RL   Genome Announc. 2:e00128-14(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUK18530.1}.
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DR   EMBL; ATSX01000001; EUK18530.1; -; Genomic_DNA.
DR   RefSeq; WP_034336536.1; NZ_ATSX01000001.1.
DR   AlphaFoldDB; W7DU21; -.
DR   STRING; 1208583.COMX_02240; -.
DR   eggNOG; COG2114; Bacteria.
DR   OrthoDB; 7293398at2; -.
DR   Proteomes; UP000019250; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd12913; PDC1_MCP_like; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019250};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          638..767
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   815 AA;  90008 MW;  2A9997905E82AA9D CRC64;
     MPAGEIVDPT KDSVNRLWRL FLRIGIPILG VILVVVVVVG VTLHSYHSTK SGILKLTHVI
     LKTEQSRVSQ EVMNYLSPAT VSSKLVVDML SHIPTEYESG MFYTYVMSSL RQTKQLQSFY
     LASEDGNFTM IERVVDKPNE VRVITLKADQ QGGQFLEEYA TVDGKKISRK SLPANAYDPR
     DRSWYKQAMQ SGKLVWSPPT LMPSKKGLVI TASIPYKDRD GKKGVFAVSI SLQQLTTFLG
     SLSISEHAQA IIVDRQKNVI ASPGLLLQFG DNEWSPDKNK IDAKYNPVIA RAYDQFLVNG
     VGIRSFKMEK DAIPEKSSLS SVVPPQSIEG NYISITSQLP ESVQRWVVLI VIPESDFSHF
     AVTGGKQNLL FSLLVVALAA AMAGVLIYQG HRMDKLGQRF KYVKNISERE NNAIEMIAST
     PEVFDPRNEA LILTEGVCNL VSAKRVSVWH IAEDQKTLIC NDLYTIEDGN HAEGVQYSIQ
     EIPDFFEAIS ETETLQVDDA ANDSRIAQFY KLFMRSSETK SVLITPVLGK KGTIGAVIIE
     DTPHLHSISH IAKIFAGLVA MRFVAAQVQF EEQDHVHGKD IQHVSTSIDK LTDDIQDNLS
     TLKPEDKTEF LLAPGSARYN NIQFETLDKD EQQGIYPAVS VMNIAFSGYL TSDIEEASKL
     IAPVKELVVV LQDIAKKYGL FYVKIMGGHL VAVAGCTKEP DVTAPIRLAH AALDMRAACL
     EMIPGMGAES NFGIGMDVGP AIGTWFGKEP RTFNLWGPTI GMSALMANMA TDGGAVQVTQ
     SAYASLRNDF LFRPRGTFYI PKVGISHTFI LAGRR
//