ID W7EYA0_PLAF8 Unreviewed; 1328 AA.
AC W7EYA0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000256|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000256|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000256|HAMAP-Rule:MF_03000};
GN ORFNames=PFBG_03824 {ECO:0000313|EMBL:EUR69272.1};
OS Plasmodium falciparum (isolate 7G8).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR69272.1, ECO:0000313|Proteomes:UP000030688};
RN [1] {ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EUR69272.1, ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|EMBL:EUR69272.1,
RC ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum 7G8.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000256|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; KE123627; EUR69272.1; -; Genomic_DNA.
DR EnsemblProtists; EUR69272; EUR69272; PFBG_03824.
DR Proteomes; UP000030688; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.860; -; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A; 1.
DR PANTHER; PTHR14005; EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT; 1.
DR Pfam; PF01399; PCI; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_03000};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000};
KW Initiation factor {ECO:0000256|HAMAP-Rule:MF_03000};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03000};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_03000}.
FT DOMAIN 435..612
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 313..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 698..790
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03000"
FT COMPBIAS 315..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1328 AA; 159301 MW; BC1B654EE97E33C8 CRC64;
MQTFQKPENA LKRAEELQFI GQNEDALQIL HSAIGHRTFR LQGWHILQEQ IMLRYIEFCL
YLEKLSLVKD GLHQYRIICQ HGNIASLGKV ITDFRDKAEE KVRLAKENVV LNKEKIEQEE
SNVDVTEKIL MASLDIEITG KHERKLQNAY RICMETYKMI LEILRATPKL EKAYHETAKK
AILFCKENKR VTEFKKLSDL LRNHYNLILR GKHKPEYQSL LKIEYHLETK IIQLEAACEL
AMWKEASNIA EDIYNLNMHD YFYKSLKSNI MMEPELVSVI DTVKSGDKNE EEKNKVNDVD
ADAKAKEDIL KGVEQQDNNV ENNNNNNNNN NDNNNNNNNN NNNNNNNNKE DEEDGKIQSG
DTITKTTDGN VGTGHNTSHS LNQSKEKLRN WIAIFYEKMA DILFVYESEL FHGLAWLKYC
FHILNFKRNM TEKEKTYICN KAVLAVLSIP VIGNKKKSED FTKQFEAHKK MSQLLGHTSV
PVKESLKNAL RIRNILNYAD ENIQKLYSLL ENQFTPLSLC LECEVLLKEL ENTEYAIYTK
KIKEVIFHKL ILQLSRVYSY ISIDYFIENI CPDHFMSWNE AEKMLVDLVY QRELEMKIDL
TMRAIHFGDK QVLNSSVMIK DSLINMYNDL QNGLKMINET IAIENEVENL TMSTLTYEEE
FAYLDKSNKN INYNTATLED IIENEVFEEK PIENEKLLKK IYEKIDEEHH KIQLLSEEHN
KKRKELLKKQ KELEQAQLKL KMEKKLLEEK LEKEKKEELA RKGEKLRIKE EKHKKKTEAA
EQMLKEIKKL CSTNTTKILM KGKYMDEITI DDILNGYVDF DDIEEAQEKL RLNERNEIIK
VRKMEAKKVD HYFRAVRQVE LSHMNRWIAL VFQEDTEILL QEQKAAEEEQ KADFEAALKE
KEEYVKFSID IEEFTKNEMK LRVEEFEKNL KAQKERLYNI LKEEKIQRAK ERRDQHIRKL
KAEEERKRRE EEEERLLKEE MERKKKEEAR KKLEEISKAQ RERDLEMDLQ MKRKKEESRR
SERSHRKSSI DDDLTWRRGD KGGSQNGDDS YRRHDDHHDG THRDRSEMRD RRDWSGRDRD
RDRERDRDRD REHRRDRDRD RERDQRDRDR DREHRRDRDR DRERDRDRDR ERDRDRDRER
DRDRDRERDR DRDRERERDR DRDRDRDIKR SDRDHKKDRD DKLDRDSRRR ERSGKPENEK
KRENDISKRN GTTEERTKNA WNLKEDDDSK AKHETSEENT KSWRNNNKVI DNEIEKAEKY
KDGEKKDGEK NKDENSSKNK ENDELANGNE ENENDEVKKN DDEEASDGGD FTVFKKKKRN
ILRFFMKA
//
