ID   W7F965_PLAF8            Unreviewed;       803 AA.
AC   W7F965;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=PFBG_02083 {ECO:0000313|EMBL:EUR72880.1};
OS   Plasmodium falciparum (isolate 7G8).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR72880.1, ECO:0000313|Proteomes:UP000030688};
RN   [1] {ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA   Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA   Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EUR72880.1, ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|EMBL:EUR72880.1,
RC   ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum 7G8.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KE123609; EUR72880.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7F965; -.
DR   EnsemblProtists; EUR72880; EUR72880; PFBG_02083.
DR   Proteomes; UP000030688; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
FT   DOMAIN          440..708
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   803 AA;  97049 MW;  AE0858A15439D5C6 CRC64;
     MDIVNINFES GWKIIREEAI EKIEKYLENE HIEKNKNLFS ATEYTRLYTV VYNMCAKKNP
     FCYSKEVYRK YGESLSMYTI DKIKPLLKNS DELNKTKILI DAWFKYSFYT KWMNKFLRYL
     DRYYVEYNSS LCLSAYTKNI FKITLFNELR EDIKNIIYEI YNNLRLQEEI DQKELFCNIV
     ELYKELDNES NEKMYEHDIE KKIVENVNNF YKKKAEEWIN DYPFDDYIIS IENAIEKEYE
     KNKSLNLNDD TCEKVTNIIV KILIYEKLNT LIDNKNNIFH LLKNNNLSSL RRTYILFSYF
     PEALTGLKKI IGEYIKMEGN ELKDKYVQLS RKMHMSKNVN NMQNVDDNTM EDNDNYIDIS
     NDDNNNNDNS NNNNIMNTEQ NDDIILCDYI EQLIKLHNHY DNIFKLSFFN ISNKNIDPNF
     NECLKDYFES FVEHEDEYFS TVKLLVIYTD NILKRDLNNE NSVDEKQKIH MNKEEKNDEQ
     TKFLMKKMSE IVEIFNYTSN KETFFEYYRV YLANRLINNI YISLHIEKKF IEQLYYLCGS
     QYTSKLGGMI QDLINNTNMN NKFYDHMKNV FNNNEIVNNN NNSIYNDHFS NYHNVKDFFS
     VKILNKGYWP TLEKIHIQLN EPFNKYIQVF EEYYKSENKN RKLEWIYELS EVILHYEFNN
     ILYNLYCNVV NAQILLLFNK YKYINYDIVK NELQIDLKSF TDHMYTSFYH FKLITSNDQI
     PDWTNSNFYI NNNFSYPNKN VYIKKTTALL SKEHEKTKED RTMAIEAAIV RVMKMHKKLF
     YDQIFDYVKK SLSSFSPTNQ VNI
//