ID W7FJQ4_PLAF8 Unreviewed; 525 AA.
AC W7FJQ4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=EH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFBG_00285 {ECO:0000313|EMBL:EUR80919.1};
OS Plasmodium falciparum (isolate 7G8).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR80919.1, ECO:0000313|Proteomes:UP000030688};
RN [1] {ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EUR80919.1, ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|EMBL:EUR80919.1,
RC ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum 7G8.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
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DR EMBL; KE123582; EUR80919.1; -; Genomic_DNA.
DR AlphaFoldDB; W7FJQ4; -.
DR SMR; W7FJQ4; -.
DR EnsemblProtists; EUR80919; EUR80919; PFBG_00285.
DR Proteomes; UP000030688; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR CDD; cd00052; EH; 1.
DR CDD; cd09913; EHD; 1.
DR Gene3D; 1.10.268.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR040990; DUF5600.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11216; EH DOMAIN; 1.
DR PANTHER; PTHR11216:SF161; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A; 1.
DR Pfam; PF18150; DUF5600; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 52..282
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 441..525
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
SQ SEQUENCE 525 AA; 61292 MW; B8B895C31E08AFEA CRC64;
MRKLLYRTEE ETVVYDNVLE GLYSLYKTYI LDLEKEFMYY HFYKPLLTSG DFLSKPMILL
LGQYSTGKTT FIKHLIEKEY CGMRIGPEPT TDKFVAVMYN EKEQLIPGNA LVSDITKPFS
QLESFGNSFL SKLECSNTSS EVLKSVTIID TPGVLSGIKQ ISRGYDFEKV IYWFAQRVDL
ILLIFDAHKL DISDEFRRCI QAIKGQDSKI RIILNKADTI NTQQLMRVYG SLMWSLGIVI
NTPEVNRVYI GSFWDKKLMH DENRTIFEEE ASDLYKEISK IPRNSTMVRL NDFIKRCRTL
KVHIYLLTHL RKKLPFFKKF LNKRKIVNSL EKIYEEVSKD YNLPLGDFPP VQFMKEKLLD
MDWMRIPKLE TKKIDRINKV LNTHIPQLLE MIPKESVTVE VSRFENQEGT IVENKLTPFL
ELTSGEIPLW VKQKYLLSPI DTSKYSDDFY KLGPDDFGKL SGEQVKQDLI KSKLPSAVLH
KIWNLADITE DGYLDLFEYS LARHFIEMKI EGFDLPAKVP KDIIK
//
