ID W7FM36_PLAF8 Unreviewed; 5625 AA.
AC W7FM36;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Dynein heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFBG_03003 {ECO:0000313|EMBL:EUR71977.1};
OS Plasmodium falciparum (isolate 7G8).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR71977.1, ECO:0000313|Proteomes:UP000030688};
RN [1] {ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EUR71977.1, ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|EMBL:EUR71977.1,
RC ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum 7G8.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123619; EUR71977.1; -; Genomic_DNA.
DR EnsemblProtists; EUR71977; EUR71977; PFBG_03003.
DR Proteomes; UP000030688; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF36; DYNEIN HEAVY CHAIN AT 93AB, ISOFORM C; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 2.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1574..1725
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1755..2013
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 2265..2569
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2671..2749
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 3739..3997
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 4010..4348
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 5025..5140
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 5171..5312
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 5318..5620
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 2009..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2977..3006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3183..3202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3615..3635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4510..4571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4778..4801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4813..4836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1464..1520
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4023..4060
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4221..4304
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2016..2034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2035..2051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3615..3631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4814..4836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5625 AA; 664280 MW; 2521CEE4E50C3394 CRC64;
MSKKNDVYEE NGEYNPKVEE LLTSALEFFN IHGLAREEVI NNIKKDENTI KLLNDFYEKN
EECLFIFNEK DCIKIYNSIL DLYKKRKNEK FLIIYKTPQS NILYLEMNND AENVIRNFLE
IFFSNFMNKN EDINSSSLLK EMKKKFNNFL LNLRIIYGET EEKLTLPYAP SEIKEENVNT
IEEYLIHFIK CYHIILRNFM NYKKKEYINC YEFLKCLKNK SEDINYLYNE IDKESFQEII
NIILEKKKNS SYKNIIENIK KEISEHKMEI LDLYTHLKPV VHFLQKLEFN KDDDIEKKYI
YITPIIHSLS ISIDKSNYLI KNCKFVFNFL SKVLINSCNQ NLNTPEIINS IYNCVDVLKI
KLYDTLNFLL NFLYIFKMYK SKNEKLQSLH EHNTYVIQRK TQIQVTSEKG NELDINMSPE
KKKNNNINID IISSYQNGNN NEENLNQEDD IKNELEEEYS YFPSISLYMY KLKILIEYLK
IYQTYMKLEK IEIPGEKGKN LTEEIHNISN DFNIINENFL DINHEILNEH EHIFINKYNI
FESRVKELNK RLICVFVYSF DNDLKKNIKL LNSFLILRDI HVIEVELIRH ASLLCQDLKK
EFILVDNLFI KNKTIIENNK KMFLEDKFQQ GQCDLDGIKN VMSNNIEEEH INKKNITGEN
IISNNIEEEH INKKNITGEN IISNNIQDDN TANTNIADET IPDVKAPSIT NNINVNINVN
INVNINVNNK MKDKLEIDKM EREIKERFED NLKRLNINKN SPLFCEVINL FTSLLKRIEQ
QYFPLKKIIK VLKFENEKTE EVKHLYKNIN EKISKYINDV SKEWFKETID VVNNFLNEYI
FKKRNDLFYV NFHPYIFMFI NNIKNFFLNN LSVNEDCLHI YNKANTFKKF INILNNITKK
YNSVLTKTLD VEKELFEEKM NNIKNRLLKG VKELKWSDDN IYEYIESVDK DMSDIYNNIS
TLHNNIVSIL NVTSNWVKKS IIEKRKRNED IYTYLNNYKN NMSILKGKLN DDFKNINMNI
KQSYDILKIK KNNIMWKNYL KFLNNIIIDK LIHLTNFLFN NLYDVMKCTK RDEQLFIIRI
NFIENKLNLD LKLTSKKTFC IETIFYKWID DFMNLCSGIR RIDIKSGDYL NEILLSLSIH
YNKNKIENFF QSTIKKSYEY LHSLTKYEHI WKIDIKKEFL SFKKKNEIQL YPTYFEYNNN
FQDSLKLINI NIPYLFPNVL AYKKLILTLK QDLNKFYHLK TYEPINFILF YSENFVEKLI
NFTKKNISLY SEYLQNFVKD VVYSINSFYE NVINNLKEIS IVDFFSKKGD SKKEILEKGE
TNTGLQKGEK NVRLKKESID NMDISKMDNN NNQMNDDNNQ MNDFDDNDKM IDLDDNDKMI
DFDDDDNNNI YDESKRYKNK NALKNEVEEK EKEKTNVSNI NKKKDIFYNL MRNLRSVKLS
RKIIPLIFQK IKEIMENLKE LDIIIKYNDI LDNIEKNKEK VEIQYNDIKE KILKYKNNEI
KNIKLEIKDF KEELTKLKKH IFKNIPSTPK DIYNFPYEKI NEFRKSFQTY KDKQKYHNEL
EILFEIDITI FDELDQIDIK LTDLKHLWDL VNSIIFFIEQ EKKKLWKNID VNSNIYLIDF
ISLYIRKNFF DLKHLSIYEY IIKELKKLSS ILPLLVDLNN ECIFDRHWNI IINISGNINN
LYTKKKENNN NNNNNNNQNN YINNTDLLNT PLSNNNKTSI MSIHTFNKEE QINNDNTYDN
EKETNNNIFL NKNIQIKYKE LTLQGFFDLK LYKHVDAVHD VIEQAKKEQK IENKIKEINV
IWKEMNFEFF KKNNYIQITN MDMILEIVDV HTSEILFFIN QKKFILFIQE TILNTQENLK
KIDEVINIWR KFLNKFERLQ PIYLNSEDIH SQLPEESKMF FNIENEYKEI IHSAAEQKNV
LQVCLNEDLF YLLSKFFKNI ELCEKALNDY LDQKKKAFPR FYFLSNIALL DILSNGKNPF
KILPYINDVF NAIKTIQFKE DLVQRGPVSE LNEQNEENDL DQKDQKDQKD QKNVNTDGKM
NGYTNDASYY GQEEDETYEG ENKKCKDIKT CESKDYIAKG VYSVENEHLE FLNELVLKGN
VENYLKDLET HLKVTIRSIL ENAKICSENL DEQNRDETMI TNYISQVVCT CNQIIVTEEI
NKCFDELENG NESAFVDYKK VLIERINKLI KLVEKTDDYN IRTKLLSLII LDVHTRDVII
SFIKKKISDS TSFDWQAQLK YYWVYDKKIN NYTCEIKLCD FKTKYLYEYI GNSGKLVITP
LTDKCYITLT QALNLILGGA PAGPAGTGKT ETTKDLSKAI GIAIFIFNCS NQMNYFNMSQ
ICIGLSQTGA WGCFDEFNRI SIEVLSVVST QIKCIFDAIK EKKTMFHFID DEIVLKKTCG
FFITMNPGYA GRTELPENLK NLFRSCSMIV PDIKFICENM LMSFGFIKAN KLSYKFVELY
QLCKELLQKN IHYDWGLRAV KVVLIQAGNL KRKYANFDEE IILMKALKDF NIPKITYEDI
PIFLGLINDL FPNVNCNIFD EKDQEKENDY DEEHKQEQQT YIIQDEEKKL YKKKKNIHHN
IDKYKSSITQ NFTNANDNKN HLSINKDNYE TNKNLLTHYQ HDICEDISQI DKTKKDVQIY
DEAHNEKSDI NELNQKTNII ANQNVNENYI NNKEYDKDSN KIDNLKQNKF MNEEKRIIIH
NFDDAIKICL KESNLQIDDN FILKVKQLKD LMDVRHCVFI LGEDGCGKSS VIDILIKSLN
KINEKCLYEI INPKSIESYE LYGYLTKNNE WIDGALSSIM RKMSRNISPY NENIKHKITL
LDGNIDAEWI ESMNTVMDDN KVLTLVSNER IPFTKEMHLF FEITNMKYAS PATVSRGGVL
FINKGDISYK LFISSWINLL NNNIAKTEFY YLFNIFYSQN IDMLRKQCKF AFDLSNLDIV
KSICNYIDYF LYKYEKYINE VIKKIENKQN EEITFMKNEN NREDLSNSNM KRKDKTTKDK
DTKEINDIHN KDIKTHEKGS QKMDKKTNSF KDKIITNDNE SKLKHQKNMN HVDDIKMNTK
NLINNEEKNI INKINYNYEI LKDYYNCFFM NSYMWVINNL IIDDKIMNSK NIFSNNIKSN
LKVKMGNDYC CNYIYNIYEN NWKHLSEYLD EDILFLQKLK WKTSEMENEE KGYEHEVVLE
GDEDDNMDDA NENMDDANEN MDDTNENMDE TNENMDDTNE NVDDIHDNMD DTHDNMDEKK
KKKLIKNKKK KKKAINNYIE NMLPNNYDDI YINTIELIRI EKMIKYCLER NQAILVYGNN
GTGKTKCIKN NINMNIEKFT HTIISINYYT NSFVLQKIIE NNVEKRNTRT YGPPNQKKHI
FFLEDLNITA KDNCDTQQTL EFLRQLLTYK LIYDRDNLDE KKFIHDISFI GTINNNTNKL
IDKRIQNKFS IINIDDISMK TFENIYKIIL KQHLLKFDDS IKCLLNNIIS FSYDLYTNIT
ENISFNLSNL APHYLFNLND IHTIFYNIIK CTNPDIYNNQ FKFLMIVFHE MQHAYINKLI
SDDHINIFTQ LFNKLVQQYF PFFKEDFEKH IDMFDSTNEP HNVEHGQDIT SNKSLTFHEN
DNVDDDTYNN NMDNGFKNDR NVNNNNIDGD DNGDGINVRT VEKTHLDMSN NLNNSNDKDN
IMKMKKSNNI NTDSYNNNNI NVKVKEKNLI YDLNKNIFTS FISIRNGLDK MYLNVKKFYV
LKEVLTEKLN EYNTTHVELP LVLFDYAIIQ ICKICRILDF NISHLMLIGF GGSGKQSLIK
LSIFINSLNL LNISTNNNYD VNNFKSDLQE FHLKCAIKPG NVHVLLLKEN DILDSFLPYI
NDLTSTGLCN DLFTKDEYLG IFSSIRNQIK YLNIGESNED VFNYYINKIK TNLKIAITHS
PISNLYRDRL IKFPSFLSNF SFIYFLPWPY EALVNVSNKF LSDIKIKQDL KKKICEHMAY
VHTSTNEMNK KYLEQKIRYN YVIPKTFLEY IYFYKNLLNV KNFEIEKSVE RLNKGLLALT
STRENVQLLQ KEIEIKITNI EEKKIEVNEI LNKVKEATEV TNKEQQIVNE EKKKTEIFTK
EAIEIQLKAD KELSEALPIM NKAKDAVNCI TKSAIQELKS LQNPPKECLD VTHAVLIALK
EIKNYSWKFA QKIMNNPTQF LSKLQKFDAE NMDEETVNLL TPFIQKKFFN YEMMKTKSSA
CAYLALWLVN IVKYNEVYKK VKPLMDKLQE ATNNKNKAQE KLDQLENKVK ELTDSVEKLR
RKMNEVNEEK NNVIKIYNES KDKLNRAENL VNMLSDEYSR WSDEIAIINS NKKFIYGDCL
LLSSFITYLG VFSSSFRIKL WKHLWLEHIK NSNILINNIT SPIDIMVQDI QIATWKNEKL
PEDIISIENA LIVSTCYRWP LLIDPQLQGL KWLKAKGGNN ITVLQFNCDH FIKKIKNVIS
KGGYLIIENI SEEIDNVIDG LLNREFIKKG NDIYIKIDNE EMLFNYPNAI NRIDKIKSFF
ETNINSNTAT TTTTTNNNNN NNNNNNDNIT INNSGASQIN NTNNDNNNIT IDNQNNYGNE
PGDSNKNYHK QNSQNMNKAF SSENLYKVNF FNLILQTKLS NPHFKPEVNS QCTLINFSVT
CEGLEEQILA IIVNIEKPEL EKQKQILVKN RNEYKIILNN LEDEILYQLS TVDSKTIIDN
ISLINSLKTT KDTSINIQKQ VADSINTENE INKTRELYRT LANEASIVYF ILILMHNINY
MYQYSLDSFI NLLLKSIEVV NSDSMKMLSN KNLDSQISNN NHMYDDDDNN NNNNGEHRHL
QKHDDKYYDS KIYLNDNDEN NNNNNDDNNN NNNNINNVYD EHMNKLIISF RKTIYSWINR
GLLEKDKLLF NCIFVFKLLE KKKIYDKDFN MDYLNFFLKP PRGKGVTENP LKEWLSDDCW
ENILILSKFK EFENLSNNIH IDAQHKFKQW CSEIQPEICK LPLEWKKLNN YSFKKLLIIR
SLRPDRITVT LEKYIKSILP NSEEIMEKKN SFVDTLESSY NFMVNSTPIL FILTPGSDFI
KYVEILGKKY KFYLNQNLHV VSLGQGQESI ALSKLELSHK EGHWIVLENI HLMAKFNLIL
ENVIDKYATE GSHPNFRCFL TSEITTNIPI SILERSIKLT NEAPTGFKEN LKRAFTFFSP
DDYEEKDLRT KNILFSLCYF HSIIVERAKF GSQGFNIKYP FSLSDLRDSA KVLFNYLDNQ
NSIKVPWNDL KYIFGEIMYG GHIVNDKDML ICKTYLNYFM KEQSLEGMQL IPFSKNIQLF
SPNNYSYEKI LKYIDTQIIF ESSILYGLNQ HAEMNFRTNE SIKLLKNILK LKLKETSTFV
EELTTGETKE NKTSNILSEI LSEIDNIFFN VEELMKSIPD DQITPLQYFL FQECTLMNSL
TSVMKNSLKE LNLAIKGEIN MTSKIESLMN ALYKDKLPEL WKNNSYSSNR NLSSWVNNLK
ERIAFLTEWF NDPLLTPKVF NISLLFNPNS FFSAIKQILS RNEKCELDKI IMQIEVTNKS
LNNIHSYPKE GAYIYGLYLD GANYDVEKNT LCDSSSKQKY FLMPVIHCKP IVSMGKIDTD
VYECPVYKTL SRGPTYVTNI KLKTKESSEK WILAGVALIL DIADD
//
