ID   W7FNW6_PLAF8            Unreviewed;       877 AA.
AC   W7FNW6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=PFBG_02128 {ECO:0000313|EMBL:EUR72926.1};
OS   Plasmodium falciparum (isolate 7G8).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR72926.1, ECO:0000313|Proteomes:UP000030688};
RN   [1] {ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA   Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA   Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EUR72926.1, ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|EMBL:EUR72926.1,
RC   ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum 7G8.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC       subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR   EMBL; KE123609; EUR72926.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7FNW6; -.
DR   SMR; W7FNW6; -.
DR   EnsemblProtists; EUR72926; EUR72926; PFBG_02128.
DR   VEuPathDB; PlasmoDB:Pf7G8_080020300; -.
DR   Proteomes; UP000030688; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
FT   DOMAIN          24..104
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   877 AA;  99964 MW;  FF628DD58E3A2C67 CRC64;
     MESSNIGQIL YATVDPNINI RSEAENKLKL AKESNFVQYI NQLSNEFCKS ENDPYLRQIA
     GLLIKNAFTS KDNYESEEKA RTWLNFPEDI KMELKNNLLV LLSQQSDKIV IGTACQIISI
     IAKIELSHNK SSELLHKLVN NIIEKNAYTK KSSTVCLAYL TEDIADVCNE SKSKYAFTQP
     DLDLILTAII NSLCEPAEES THCANMKVLY NLMSFIEHNF KTQVERDIIM KTVIDGCKDT
     ERQSVQIAAY ECLINIVSYF YSYLDAYMYA IGPLTWVAIE SENERIAISA IEFWNTVCEE
     ETFIDQYELQ EGKKNHNIVK QAMVFLLPKI FNAMITQESE DIDIDAWTLS MASATFLALS
     AQLLKNDIVE PVISFVEENF IHEDWRRRDA AVLAYGSIME GPDTEKLKPL VEESVGQLSE
     VLRDPSVAVR DTAAWTIGKI TTYHSEIIYN VLGSYNDSNS LYGILLERLN DYPRVAANVC
     WVFNQLAVNK RTSYNKMTNS YVTDLDDSFC VLCKKLIDVS SREDSDIRNL REAAFNALNV
     VILSVSDNCL KYMIELLSHM MYLLTNTYLN PLTEEVKSLQ GYYCGTMQFI INRLGNQCKP
     FLKPIYLSIF RLFEIRTDIC EDALLACSAI INVMAEDFRE HLKTFLNVIF KGLKNVSETS
     TCKICIEMIS DICIPWTSEY EKEMEAILEC LWEALKTFGV HDSIKISILT VLGDIATALN
     RSFSKYLNFF ANILSETSKI TITSGSPDSD DWVNYVFELR DAILLTYSNI IYALIDGNEI
     NKLKPYIPNI LDFIELILIK EINHFNAQNF QNSVSLLGDL VHAYGYELIE NSKLTDLIIS
     VYGKIDILSS QGDEKCETCV SKIKWLKRIC NARLSQK
//