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Database: UniProt
Entry: W7HR95_9PEZI
LinkDB: W7HR95_9PEZI
Original site: W7HR95_9PEZI 
ID   W7HR95_9PEZI            Unreviewed;      1098 AA.
AC   W7HR95;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   05-JUN-2019, entry version 32.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=DRE_04264 {ECO:0000313|EMBL:EWC46541.1};
OS   Drechslerella stenobrocha 248.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Orbiliomycetes;
OC   Orbiliales; Orbiliaceae; Drechslerella.
OX   NCBI_TaxID=1043628 {ECO:0000313|EMBL:EWC46541.1};
RN   [1] {ECO:0000313|EMBL:EWC46541.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=248 {ECO:0000313|EMBL:EWC46541.1};
RA   Liu X., Zhang W., Liu K.;
RT   "Drechslerella stenobrocha genome reveals carnivorous origination and
RT   mechanical trapping mechanism of predatory fungi.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KI966417; EWC46541.1; -; Genomic_DNA.
DR   EnsemblFungi; EWC46541; EWC46541; DRE_04264.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0000784; C:nuclear chromosome, telomeric region; IEA:EnsemblFungi.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:1904161; P:DNA synthesis involved in UV-damage excision repair; IEA:EnsemblFungi.
DR   GO; GO:1903459; P:mitotic DNA replication lagging strand elongation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      118    464       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      528    962       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1000   1074       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     40       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W7HR95}.
FT   COILED       44     64       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1098 AA;  124038 MW;  9478020656176072 CRC64;
     MAAAAVTKRV LNDQTASHNS HFNSAVNKKR KLDTVGPDQA NPKLAKLAQT KSTFEEDLGR
     LTQEIGGLKG ANAEKDQKWA RPSLDDWVPN EADLVFQQID VEEGVWDDKT CVRLFGVTET
     GHSVLLHVTD FLHYIYLQAP VGFDHSHIQP YQEFVQQRVG GGNETVVASV QVVMRENLYG
     FQGNQKSPYI KITVTEPKYI PRVRKFIETG NANYAGMWRG LEGNIMTFDN IQFIMRFMVD
     TKMSGMSWVE VKKDAYKYIQ PGLNGGRVGA AQIEAVCHYR DLVTHASEGE WSKIAPLRIM
     SFDIECAGRK GIFPEPKIDP VIQIASVVTR YGDTQPFIRN VFCLETCALI VNTQVCEFSR
     EDQMLRSWTQ FLKEVDPDVL IGYNIANFDF PYLLDRADTL KVKDFPYWTR IKGMKSEAKS
     TNFSSKQMGN RDSKATNTNG RIQLDLLQLV QRDYQLRSYT LNSVCAHFLN EQKEDVHHTM
     ITELFNGTPE SRRRLAVYCL KDAYLPQRLM DKLMCLVNYT EMARVTGVPF NMLLSRGQQV
     KFLSQLFRKA AEQSLVVPNL EQQGGGDDGE KYEGATVIEP TRGFYKEPVA TLDFSSLYPS
     IMMAHNLCYT TFTKQEHMDR MGLKLGTDYH ETPNGDLFVD ASVRKGLLVT IFEDLLGARK
     KAKNDLKNET DAFKKAVLNG RQLALKISAN SVYGLTGATN GKLPCLAIAS SCTSYGRQMI
     EATKAEVEKK YTVANGYSHD AQVIYGDTDS VMIKFGPKDL KKVMELGQEA ADYVSSKFIN
     PIKLEFEKVY FPYLLINKKR YAGLYWTNPV KYDKMDTKGI ETVRRDNCRL VQTVIETVLK
     KILIEQDENG AQTYVKDIIS DLLQNKIDMS NLVITKALSK ENYAAKQAHV ELAERMRKRD
     AGSAPTLGDR VAYVIIKGAG GAKNYEKSED PIYVLEHNVP IDTKYYLDQQ LAKPLQRIFE
     PILGEKRANQ LLTGDHTRTI SVAAPTMGLL TKFTTKTQTC MGCRTPLTRK EESGGAVCHN
     CQGRSAELYQ KTLAQVSELE VRFGRLWTQC QRCQGSLHCE VICSSRDCPI FYMRMKAKKE
     VEGAGKELAR FDYGLSAW
//
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