ID W7IVA4_9PSEU Unreviewed; 875 AA.
AC W7IVA4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Sensory box histidine kinase {ECO:0000313|EMBL:EWC60667.1};
GN ORFNames=UO65_4091 {ECO:0000313|EMBL:EWC60667.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC60667.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC60667.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC60667.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC60667.1}.
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DR EMBL; AYXG01000148; EWC60667.1; -; Genomic_DNA.
DR AlphaFoldDB; W7IVA4; -.
DR STRING; 909613.UO65_4091; -.
DR PATRIC; fig|909613.9.peg.4092; -.
DR eggNOG; COG2172; Bacteria.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2208; Bacteria.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR CDD; cd00130; PAS; 2.
DR CDD; cd07043; STAS_anti-anti-sigma_factors; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR Pfam; PF13466; STAS_2; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SMART; SM00331; PP2C_SIG; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 2.
DR PROSITE; PS50801; STAS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EWC60667.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019277};
KW Transferase {ECO:0000313|EMBL:EWC60667.1}.
FT DOMAIN 1..68
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 70..122
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 285..355
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 789..838
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 714..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 94135 MW; 8EA884C8B5772672 CRC64;
MLGGLPLVVW EADARTGAFT FVSEHAETLL GYPVTRWTGD RGFWASITHP DDRAAAAEFR
ARNVAERDDF ESDYRVTAAD GRVLWVHDVV HVVRGAGGEP RTLRGLMVDV TARRFDEDRE
RFLAELELAL QPLTDAEQIM AEAARGLGEH LGADRCAYAR AEADEDHFLM SGDHATGLPH
LPGRYSMADF GAGCLRAMRA GEPWVVTDSG TDPAVRDLDA YRLTGIRAVI CVPLLKAGRF
TAAMAVHQAS PRAWTDDDVE LVGDVAARCW ESLERAHAAR ELRESERRHR MLFEHAADAV
WMADHDLRLV EVNPAACALL GHSRERLLSM SVPDLLLPGS PDRLADLVAR VATGEQVTEV
WEVRHASGAT ISVELSIAGT PAGLQAIGRD VTARRAAEAE REAELRREHE IAQALQHSLL
PRELPDLARL ATAARYRSGS RHAQTGGDWY EVLPTSRTSV AMVVGDVVGK GPRAAAVMGQ
LRSALAAYLL DGHSPASALQ RLDLFATRNP GAVGSTCACL LLDWETGVLR WSAAGHPPPL
VVDETGARFL TGTTGTLLGA DGTFTENEVH LSPGTSLVLY TDGLVERRDH LIDDDLARLA
DLVAPLHALD PETITDRITT ALLADGHDDD VALVVARYLP APLSRRDVPA TPAVLAEVRT
DISRWGALAA LPQDTVIDLN LILGEATANS VEHAYPNGGG TLDYSVTRGA GGSLRTQVRD
RGRWRPPPAD PGHRGRGLAM IRSLAATTIQ HGPEGTLIDA RLPTNTETTP TTTPPPQVER
TPTTPDHRVR INGDLDLTGA AHWRPELLAH AAHGEPLTVD LTEVSYLSSS GMALLLDMAA
RTTVTVRVTE GSGPARVLGL SALPAHTVAV EVVTT
//
