ID W7IXX0_9PSEU Unreviewed; 414 AA.
AC W7IXX0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Ribonuclease D {ECO:0000313|EMBL:EWC61702.1};
DE EC=3.1.26.3 {ECO:0000313|EMBL:EWC61702.1};
GN ORFNames=UO65_3060 {ECO:0000313|EMBL:EWC61702.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC61702.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC61702.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC61702.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC61702.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYXG01000103; EWC61702.1; -; Genomic_DNA.
DR RefSeq; WP_035282989.1; NZ_AYXG01000103.1.
DR AlphaFoldDB; W7IXX0; -.
DR STRING; 909613.UO65_3060; -.
DR PATRIC; fig|909613.9.peg.3062; -.
DR eggNOG; COG0349; Bacteria.
DR OrthoDB; 144122at2; -.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-EC.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd06142; RNaseD_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR041605; Exo_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF18305; DNA_pol_A_exoN; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EWC61702.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019277}.
FT DOMAIN 233..313
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 44760 MW; 1C2DED5CD22A96CE CRC64;
MTTPASGPSG SEPPAPVLLT EPAEGTPDVV ADLDTLERAA RRIAAGTGPI AVDTERASGY
RYSQRAYLVQ VRREGAGTFL IDPVAVDDRV EPLVEALGTG EWVLHAASQD LPCLADLGLH
PAKLFDTELA GRLAGFERVA LGTLVELLLG YHLEKGHGAA DWSRRPLPVD WLNYAALDVE
LLVQLRDALE AELREQGKLE WALEEFEALR TAPPAPPRKE PWRRTSGIHS VRTQRGLAGI
RALWEARDTL ARERDIAPGR VLPDSAIIQA ASVNPADESA LLQLPVFKGR AQRRQVGTWM
RALRTAAELP KSELPDPAPA TDGPPPANRW ADKDPEAAAR LSAARTALGK IAEENRLPVE
NLLQPDLLRR TCWTPPADLD VEAVTETLHA GGARTWQTNL VAEAVATALR ATAS
//
