ID W7J050_9PSEU Unreviewed; 352 AA.
AC W7J050;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Nucleoside-diphosphate-sugar epimerase {ECO:0000313|EMBL:EWC62342.1};
GN ORFNames=UO65_2329 {ECO:0000313|EMBL:EWC62342.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC62342.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC62342.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC62342.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC62342.1}.
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DR EMBL; AYXG01000081; EWC62342.1; -; Genomic_DNA.
DR AlphaFoldDB; W7J050; -.
DR STRING; 909613.UO65_2329; -.
DR PATRIC; fig|909613.9.peg.2336; -.
DR eggNOG; COG0451; Bacteria.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd08948; 5beta-POR_like_SDR_a; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR32487; 3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE; 1.
DR PANTHER; PTHR32487:SF0; 3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 172..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..239
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 352 AA; 39007 MW; 22EEC720B4A2E33A CRC64;
MSDNVALVVG ARGVIGGNLV HHLEGLGNWQ VIGLSRRGGE GSERVRHISV DLLDADDTRA
KLAGLTGVTH VFYAAYQDAP TFAGLVEPNQ RMLVNVLEAV EPVAAGLRHV QLMQGYKVYG
AHLGPFKTPA REDDPPHMPP EFNVEQQAFV ERAQRGKDWT WSALRPSVVC GFALGIPMNL
AMVIAVYATI SKHLGVPLRF PGKPGAYRSL IEMTDAGLLA EAMVWAATDP AAANQAYNIN
NGDLFRWEEM WPRIADYFDL PVAPGLPMSL ATVMADKEQV WREITAEHDL APTPYRDVSS
WAFGDAVFSW DYDFIADGSK ARRHGFHHHV DTTEMFPRIF DEMRARKIIP PR
//
